SPECT CAMERA FOR MAMMOGRAPHY OF ISOLATED BREAST

这项建议是为发展一个原型单光子 用于检测的计算机断层扫描（SPECT）闪烁照相机， 使用放射性示踪剂的乳腺肿瘤功能成像。 的 相机将有一个固定的环形晶体探测器，围绕一个 垂下的乳房在密切的接近和形象，它的三维， 其整体，不依赖于其他体内的放射性示踪剂浓度 机关 这台相机的结构是由独特的 闪烁相机创新，在第一阶段期间开发的， 项目，它修改了光的方向和接收的方式， 照相机的光电倍增管。 环形相机预计将提供 尽可能高的灵敏度、分辨率和肿瘤对比度， 通过电子照相的方式实现。这些改进将导致 更高的特异性和检测肿瘤比任何其他可能的 手段 建议的商业应用 由于其较高的特异性和可检测性， 一个孤立的乳房有可能与 或在许多情况下取代现有的诊断方法。

This proposal is for the development of a prototype single photon computed tomography (SPECT) scintillation camera for the detection and functional imaging of breast tumors using radioactive tracers. The camera will have a stationary annular crystal detector, to surround a pendant breast in close proximity and image it three-dimensionally, in its entirety, independent of radiotracer concentrations in other body organs. The construction of this camera is made possible by unique scintillation camera innovations, developed during phase I of this project, which modify the way that light is directed and received by the camera s photomultipliers. The annular camera is expected to provide the highest possible sensitivity, resolution and tumor contrast that can be achieved by scintigraphic means. These improvements should result in higher specificity and detection of tumors than is possible by any other means. PROPOSED COMMERCIAL APPLICATION Because of its higher specificity and detectability, annular SPECT of an isolated breast has the potential of being used in conjunction with or replacing existing diagnostic methods in many instances.