REDUCING LIGHT-SPREAD IN COINCIDENCE DETECTION CAMERAS

减少重合检测相机中的光扩散

• 批准号: 6016554
• 负责人: SEBASTIAN GENNA
• 金额: $ 10万
• 依托单位: DIGITAL SCINTIGRAPHICS, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6016554
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; imaging /visualization /scanning; light scattering; neoplasm /cancer diagnosis; photomultiplier; scintillation cameras

This proposal addresses a deficiency of scintillation camera technology, which has direct bearing on cancer imaging in the whole-body using recently developed coincidence detection (CD) methods. These cameras are currently being used as an alternative to the more costly positron imaging tomography (PET) systems for the detection of cancer of the whole body. Although they are gaining wide acceptance, primarily because of their cost and versatility, their sensitivity for tumor detection is much poorer than that of PET. Unquestionably, the performance of CD cameras can be improved by reducing spread of light from gamma ray scintillations produced their crystal detectors. It is suggested in this proposal that light spread can be reduced substantially by modifying the architecture of the crystal. The new designs are expected to make it possible to construct thicker crystals for use in CD cameras, thereby increasing sensitivity by a factor of two. The methods proposed should reduce light spreads in a 30 mm crystal to the same as those exhibited by a 10 mm crystal so as to preserve resolution characteristics for lower energy single- photon imaging applications. This change will also improve the energy and spatial resolutions of CD and, more significantly, increase their count-rate capability (their severest limitation) by several-fold. Ultimately (Phase II and III), this development should lead to the production of scintillation camera plates that will be offered to all camera manufacturers, or as retrofits to existing cameras. There are approximately 3500 camera plates produce a year of which about half are designed for CD imaging. PROPOSED COMMERCIAL APPLICATION This research is expected to make available scintillation crystals for coincident detections (CD) cameras that perform much better than current camera crystals. These camera plates can be sold to all camera manufacturers or retrofitted to existing cameras. The market for CD crystal plates is estimated to be approximately 35 million dollars.

该提议解决了闪烁照相机技术的不足，该技术使用最近开发的符合检测（CD）方法对全身中的癌症成像具有直接关系。 这些相机目前正被用作更昂贵的正电子成像断层扫描（PET）系统的替代品，用于检测全身癌症。 虽然它们正在获得广泛的接受，主要是因为它们的成本和多功能性，它们对肿瘤检测的灵敏度比PET差得多。毫无疑问，CD相机的性能可以通过减少晶体探测器产生的伽马射线衍射的光传播来提高。 在该提议中建议，可以通过修改晶体的结构来大幅减少光扩散。 新的设计预计将使制造用于CD相机的更厚晶体成为可能，从而将灵敏度提高两倍。 所提出的方法应将30 mm晶体中的光扩散减少到与10 mm晶体所表现出的光扩散相同，以便为较低能量的单光子成像应用保留分辨率特性。 这种变化也将提高CD的能量和空间分辨率，更重要的是，将其计数率能力（最大限度）提高数倍。最终（第二和第三阶段），这一发展将导致生产闪烁相机板，将提供给所有相机制造商，或作为现有相机的改造。 每年大约生产3500个照相机底片，其中大约一半是为CD成像设计的。拟议的商业应用这项研究预计将使可用的闪烁晶体的重合检测（CD）相机的性能比目前的相机晶体好得多。 这些相机板可以出售给所有相机制造商或改装到现有的相机。 据估计，CD水晶盘的市场约为3500万美元。