Australian Heritage: constructing the first Aboriginal reference genome

澳大利亚遗产：构建第一个原住民参考基因组

• 批准号: DP190103705
• 负责人: A/Prof Bastien Llamas
• 金额: $ 30.49万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-08-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190103705
• 关键词: Australian; Heritage; constructing; first; Aboriginal

This project aims to use DNA sequencing technologies to generate the first complete and accurate Aboriginal genomes, along with maps of genomic variation around Australia. It will combine a range of advanced analytical methods to integrate past and present indigenous genetic diversity from human populations around the world into a new pan-human reference genome. This project will lead to a step change in our understanding of global human genomic variants and provide a range of new targets relevant to medical biology, while significantly improving our knowledge of human genetic history and its consequences in the modern day.

该项目旨在利用DNA测序技术生成第一个完整和准确的土著基因组，以及澳大利亚各地的基因组变异图。它将结合一系列先进的分析方法，将过去和现在来自世界各地人群的土著遗传多样性整合到一个新的泛人类参考基因组中。该项目将导致我们对全球人类基因组变异的理解发生重大变化，并提供一系列与医学生物学相关的新目标，同时显著提高我们对人类遗传历史及其在现代后果的认识。