An integrated molecular approach to human evolution

人类进化的综合分子方法

• 批准号: FT170100448
• 负责人: A/Prof Bastien Llamas
• 金额: $ 47.85万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT170100448
• 关键词: integrated; molecular; approach; human; evolution

This project aims to use the power of High Throughput Sequencing to investigate a range of genetic mechanisms that facilitate rapid human adaptation to diverse environments. This project expects to create the first ultra-high-quality Aboriginal Australian reference genome using Single Molecule, Real-Time Sequencing, which will expand the known range of human genomic and non-genomic variation. The results should offer the first detailed, long-term reconstruction of the evolutionary history of human adaptability to specific environmental and cultural stressors. Importantly, the translation of the results to biomedical research will shed new light on the origins of modern diseases.

该项目旨在利用高重复序列测序的力量来研究一系列促进人类快速适应不同环境的遗传机制。该项目预计将使用单分子实时测序技术创建第一个超高质量的澳大利亚土著参考基因组，这将扩大人类基因组和非基因组变异的已知范围。 研究结果将首次提供人类适应特定环境和文化压力的进化史的详细、长期重建。重要的是，将结果转化为生物医学研究将为现代疾病的起源提供新的线索。