课题基金 / 基金详情

BREATH COLLECTION APPARATUS FOR DIAGNOSIS OF DISEASE

BREATH COLLECTION APPARATUS FOR DIAGNOSIS OF DISEASE
用于疾病诊断的呼吸采集装置
批准号:
2644327
负责人:
Michael Phillips
金额:
$9.02万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-09-30 至 1999-09-29

项目摘要

项目成果

Michael Phillips的其他基金

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中文摘要
翻译
描述(改编自申请人摘要):的组成
英文摘要
DESCRIPTION (Adapted from applicant's abstract): The composition of volatile organic compounds (VOCs) in the breath varies with the composition of VOCs circulating in the blood. Therefore, analysis of breath provides a non-invasive probe of blood chemistry. Recent studies with a highly sensitive Series 2.0 breath collecting apparatus (BCA) have shown that VOCs in breath are markers of lung cancer, breast cancer, heart transplant rejection. In order to build on these findings and establish the clinical value of breath testing , it will be necessary to perform the next round of clinical studies. This will require an improved BCA incorporating evolutionary improvements. An improved Generation 3.0 BCA will be constructed, and evaluated in bench top and human studies. The aim is to develop an improved and "user- friendly" BCA which will permit the routine collection and assay of VOCs present in breath in picomolar concentrations. It is planned to employ this BCA in clinical studies to determine the value of breath testing as a non-invasive tool for the detection of disease. FDA approval will be obtained for the BCA, breath tests for disease, and to market the technology for clinical diagnostic applications. PROPOSED COMMERCIAL APPLICATION: Breath testing could provide a new and non-invasive diagnostic tool for monitoring the severity of several diseases, including lung cancer, breast cancer, ischemic heart disease and heart transplant rejection. In practice, the breath collection apparatus (BCA) would be employed by an end user (e.g. a physician or a hospital) to collect breath samples from patients; the samples would them be sent to a central laboratory for analysis by gas chromatography and mass spectroscopy. Automated analysis of the breath chromatogram could then identify the patient's risk for a particular disease, such as lung cancer, and these results would then be communicated to the physician.
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Topic 393: Breath Test for Biomarkers of Radiation Exposure
  • 批准号:
    10020557
  • 项目类别:
  • 资助金额:
    $30.0万
  • 财政年份:
    2019
  • 负责人:
    Michael Phillips
  • 依托单位:
Validation of a rapid point-of-care breath test for breast cancer
  • 批准号:
    9133217
  • 项目类别:
  • 资助金额:
    $107.19万
  • 财政年份:
    2016
  • 负责人:
    Michael Phillips
  • 依托单位:
Validation of Point-of-Care Breath Test for Pulmonary TB
  • 批准号:
    8832195
  • 项目类别:
  • 资助金额:
    $23.13万
  • 财政年份:
    2015
  • 负责人:
    Michael Phillips
  • 依托单位:
Point of Care Breath Test for Biomarkers of COPD
  • 批准号:
    8757326
  • 项目类别:
  • 资助金额:
    $22.3万
  • 财政年份:
    2014
  • 负责人:
    Michael Phillips
  • 依托单位: