NEW BIOMARKER OF BREAST CANCER IN BREATH

呼吸中乳腺癌的新生物标志物

• 批准号: 2868012
• 负责人: Michael Phillips
• 金额: $ 10万
• 依托单位: MENSSANA RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-01 至 2000-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2868012
• 关键词: alkanes; biomarker; breast neoplasms; breath tests; clinical research; diagnosis design /evaluation; female; human subject; neoplasm /cancer diagnosis; noninvasive diagnosis; oxidative stress

DESCRIPTION (adapted from the applicant's abstract): Oxidative stress in cancer cells generates oxygen free radicals which degrade cell membranes by lipid peroxidation. Polyunsaturated fatty acids are converted to alkanes that are excreted in the breath or degraded by cytochrome p450 enzymes. In a pilot study, an advanced new test for breath alkanes distinguished women with breast cancer from cancer-free controls. Hypothesis: The breath alkane test may provide a new biomarker of breast cancer. Experimental plan to test the hypothesis: Breath alkane tests will be performed in 170 women undergoing biopsy of a breast mass. The short-term aim of the research is to determine the sensitivity and specificity of the breath alkane test as a biomarker to breast cancer. Long-term aims of the research: If the breath alkane test is confirmed as a sensitive and specific biomarker of breast cancer, the instrumentation will be developed into a portable purpose-built apparatus. This device would be comparatively inexpensive and suitable for rapid mass screening of large populations of women for breast cancer. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述（改编自申请人的摘要）：癌症中的氧化应激 细胞产生氧自由基，通过脂质降解细胞膜 过氧化作用多不饱和脂肪酸转化为烷烃， 通过呼吸排出或被细胞色素p450酶降解。以试点 研究，一种先进的呼吸烷新测试区分女性乳房 与无癌对照组相比的差异。假设：呼气烷烃测试可能 提供了一种新的乳腺癌生物标志物。试验计划， 假设：呼吸烷烃测试将在170名妇女进行， 乳房肿块的活组织检查研究的短期目标是确定 呼气烷烃试验作为乳腺癌生物标志物的敏感性和特异性 癌研究的长期目标：如果呼气烷烃测试得到证实， 作为乳腺癌的敏感和特异性生物标志物， 将发展成为一种便携式专用仪器。这个装置将是 相对便宜，适合快速大规模筛选 女性乳腺癌的发病率。 拟议商业应用：不可用

项目成果

Volatile markers of breast cancer in the breath.

• DOI: 10.1046/j.1524-4741.2003.09309.x
• 发表时间: 2003-05-01
• 期刊: The breast journal
• 作者: Phillips, Michael;Cataneo, Renee N;Wong, Cynthia
• 通讯作者: Wong, Cynthia