DNA CHARCOAL PLASMA SORPTION FOR TREATMENT OF SLE
DNA CHARCOAL PLASMA SORPTION FOR TREATMENT OF SLE
批准号:
2717405
负责人:
STEPHEN R ASH
金额:
$10.0万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-08-15 至 1999-07-14
中文摘要
描述:(改编自申请人的摘要)长期
英文摘要
DESCRIPTION: (Adapted from the applicant's abstract) The long-term
objective of this proposal is to develop an extracorporeal sorbent based
treatment for systemic lupus erythematosus (SLE) and other immunologic
disorders. A defining feature of SLE is the presence in the blood of
anti-DNA antibodies (Ab), the level of which is correlated with the
severity of disease symptoms. Current treatments are marginally effective
or limited by severe side effects. The BioLogic-DT sorbent-based
hemodialysis system has proven useful in the treatment of liver failure
with coma. This technology has been enhanced by combining it with a PF
auxiliary system which permits the direct treatment of plasma with
powdered sorbents to remove large or protein bound molecules. Use of DNA
immunosorbent in the PF unit of the BioLogic-DTPF will provide a therapy
for the hematologic manifestations of acute exacerbations of SLE while
reducing the anti-DNA Ab level. DNA will be bound to activated charcoal
which has been primed with trichlorovinylsilane using gamma radiation, and
quantified using standard methods. The capacity of DNA-charcoal to bind
monoclonal anti-DNA Ab from purified protein solution or serum will be
determined using an ELISA method. The rheologic properties of the DNA-
charcoal suspension affecting its behavior in the PF sorbent pumping
system will also be evaluated.
PROPOSED COMMERCIAL APPLICATION:
Systemic lupus erythematosus (SLE) is a chronic, relapsing immune
disorder, the severity of which is linked to anti-DNA antibody levels.
The Lupus Foundation estimates that approximately 1.4 million Americans
have SLE, and that 75% of patients will experience severe episodes which
may be treatable with DNA immunoadsorption. DNA immunoadsorption has the
potential to reduce morbidity and organ damage in these patients by
reducing or eliminating the anti-DNA antibodies and possibly obviating the
need for drug therapies with severe toxic side effects.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
MethLock vs. heparin as dialysis catheter lock
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批准号:6935046
-
项目类别:
-
资助金额:$10.0万
-
财政年份:2005
-
负责人:STEPHEN R ASH
-
依托单位:
MethLock vs. heparin as dialysis catheter lock
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批准号:7264869
-
项目类别:
-
资助金额:$176.21万
-
财政年份:2005
-
负责人:STEPHEN R ASH
-
依托单位:
MethLock vs. heparin as dialysis catheter lock
-
批准号:7341763
-
项目类别:
-
资助金额:$89.94万
-
财政年份:2005
-
负责人:STEPHEN R ASH
-
依托单位:
Pheresis Treatment of Bioterrorism-Induced Sepsis
-
批准号:6885339
-
项目类别:
-
资助金额:$50.69万
-
财政年份:2004
-
负责人:STEPHEN R ASH
-
依托单位:
Pheresis Treatment of Bioterrorism-Induced Sepsis
-
批准号:6742356
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项目类别:
-
资助金额:$50.47万
-
财政年份:2004
-
负责人:STEPHEN R ASH
-
依托单位:
SUB-Q ULTRAFILTER/INFUSION DEVICE (SQUID) FOR INSULIN
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批准号:6020112
-
项目类别:
-
资助金额:$10.0万
-
财政年份:1999
-
负责人:STEPHEN R ASH
-
依托单位:
BIOREACTOR WITH DIRECT PLASMA CONTACT FOR LIVER ASSIST
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批准号:2539002
-
项目类别:
-
资助金额:$9.99万
-
财政年份:1998
-
负责人:STEPHEN R ASH
-
依托单位:
BIOIMPEDANCE CONTROL OF ULTRAFILTRATION ON HEMODIALYSIS
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批准号:2150850
-
项目类别:
-
资助金额:$10.0万
-
财政年份:1995
-
负责人:STEPHEN R ASH
-
依托单位:
LIVER ASSIST BY PUSH-PULL SORBENT-REGENERATIVE PHERESIS
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批准号:2148304
-
项目类别:
-
资助金额:$10.0万
-
财政年份:1995
-
负责人:STEPHEN R ASH
-
依托单位:
ENHANCING EFFICACY OF BIOLOGIC-DT LIVER ASSIST DEVICE
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批准号:2147567
-
项目类别:
-
资助金额:$5.4万
-
财政年份:1994
-
负责人:STEPHEN R ASH
-
依托单位:
MONITORING DRUG THERAPY THROUGH SMARTCHART
-
批准号:3495871
-
项目类别:
-
资助金额:$5.0万
-
财政年份:1989
-
负责人:STEPHEN R ASH
-
依托单位:
BIOLOGIC-PD--A NIGHTTIME PERITONEAL CYCLER
-
批准号:3495757
-
项目类别:
-
资助金额:$5.0万
-
财政年份:1988
-
负责人:STEPHEN R ASH
-
依托单位:
BIOLOGIC-DC SYSTEM FOR REMOVING CO2 FROM BLOOD
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批准号:3495790
-
项目类别:
-
资助金额:$5.0万
-
财政年份:1988
-
负责人:STEPHEN R ASH
-
依托单位:
SORBENT SYSTEM FOR HEMODIALYSIS
-
批准号:3495709
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项目类别:
-
资助金额:$5.0万
-
财政年份:1987
-
负责人:STEPHEN R ASH
-
依托单位:
INDWELLING FISTULA ACCESS DEVICE FOR HEMODIALYSIS
-
批准号:3495692
-
项目类别:
-
资助金额:$5.0万
-
财政年份:1987
-
负责人:STEPHEN R ASH
-
依托单位:
SINGLE-ACCESS, SORBENT-BASED HOME DIALYSIS
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批准号:3507276
-
项目类别:
-
资助金额:$4.73万
-
财政年份:1984
-
负责人:STEPHEN R ASH
-
依托单位:
SINGLE-ACCESS, SORBENT-BASED HOME DIALYSIS
-
批准号:3507274
-
项目类别:
-
资助金额:$45.27万
-
财政年份:1984
-
负责人:STEPHEN R ASH
-
依托单位: