SORBENT SYSTEM FOR HEMODIALYSIS

Ash Medical开发了一种新的基于sorpion的单通道 一种安全、简单、便携血液透析机。 的 BioLogic-HD目前使用板式透析器主动泵送 血液，同时透析血液，和Redy HiSorb柱， 再生透析液。 以前的研究已经证明， 吸附剂悬浮液可以流过过滤器的筛网支撑件， 板式透析器，取代Redy柱。 吸附剂悬浮液 在透析液中可以产生更高的尿毒症毒素清除率， 以及使用密度轻、粒径小的吸附剂， 其难以放入柱中，例如沸石。 目前的建议是进一步开发一种吸附剂悬浮液 能有效清除尿毒症毒素， 物质，并尽量减少潜在有害物质的释放 物质. 该吸附剂悬浮液将包括粉末状的 木炭和包含钙-钠负载的微胶囊 沸石和尿素酶。 体外试验将证明安全性和 吸附剂悬浮液的功效。 如果这些测试是积极的， 将准备IDE以允许吸附剂的临床试验 BioLogic-HD系统中的悬浮液。

Ash Medical has developed a new sorbent-based, single-access hemodialysis machine which is safe, simple, and portable. The BioLogic-HD currently uses a plate dialyzer to actively pump blood while dialyzing the blood, and a Redy HiSorb column to regenerate dialysate. Previous research has proven that a thick sorbent suspension can flow through the screen supports of the plate dialyzer, replacing the Redy column. A sorbent suspension in the dialysate can produce higher clearances of uremic toxins, and use of sorbents with light density and small particle size, which are difficult to put into columns, such as zeolites. The current proposal is to further develop a sorbent suspension which will effectively remove uremic toxins, release appropriate substances, and minimize release of potentially harmful substances. This sorbent suspension will include powdered charcoal, and microcapsules which include calcium-sodium loaded zeolites and urease. In vitro tests will demonstrate the safety and efficacy of the sorbent suspension. If these tests are positive, an IDE will be prepared to allow clinical trials of the sorbent suspension in the BioLogic-HD system.