BIOLOGIC-DC SYSTEM FOR REMOVING CO2 FROM BLOOD

该项目的目标是开发一种体外装置，以 从相对较小的流量中去除大量二氧化碳 出血率。这种脱羧剂设备可以帮助 呼吸器无法清除足够的二氧化碳或无法使用时的患者 用于中度二氧化碳滞留患者的呼吸器。 脱羧器系统将通过开发一种新的 用于生物透析机的一次性包装。这台机器 旨在通过单一血液通道执行透析 (锁骨下导管或针)使用平板透析器 用于清除化学物质和抽血。我们将设计一个 含氢氧化钙悬浮液的一次性包装(DC包装) 它将通过筛板透析器来回移动 保持流动性的方式。在透析器里，钙 氢氧化物将它的羟基交换成碳酸氢盐，去除 几乎所有的血液中的碳酸氢盐都没有过量的钙或 羟基回到血液中。第一阶段的体外试验将 确定二氧化碳的去除率、钙的返回量和pH值的变化 由生物-DC系统引起。这些研究将表明 该系统是否有潜力帮助患者 呼吸衰竭。

The goal of this project is to develop an extracorporeal device to remove large amounts of carbon dioxide from a relatively small flow rate of blood. This decarboxylator device could help support patients when respirators fail to remove sufficient C02, or be used in place of respirators in patients with moderate C02 retention. The decarboxylator system will be created by developing a new disposable package for the BioLogic dialysis machine. This machine is design to perform dialysis through a single blood access (subclavian catheter or needle) using a plate dialyzer both for chemical clearance and for pumping blood. We will design a disposable package (DC pack) with a suspension of calcium hydroxyl which will move through a screen plate dialyzer in a to-and-fro manner to maintain fluidity. Within the dialyzer, the calcium hydroxide will exchange its hydroxyl for bicarbonate, removing almost all of the blood bicarbonate without excessive calcium or hydroxyl return to the blood. In vitro tests during Phase I will determine the CO2 removal rate, calcium return, and pH changes caused by the BioLogic-DC system. These studies will indicate whether the system has potential for assisting patients in respiratory failure.