BIOLOGIC-DC SYSTEM FOR REMOVING CO2 FROM BLOOD

用于去除血液中二氧化碳的 BIOLOGIC-DC 系统

• 批准号: 3495790
• 负责人: STEPHEN R ASH
• 金额: $ 5万
• 依托单位: ASH MEDICAL SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-09-30 至 1989-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3495790
• 关键词: adult respiratory distress syndrome; clinical biomedical equipment; cow; hemodialysis; human subject; hypercapnia; respiratory hypoxia

The goal of this project is to develop an extracorporeal device to remove large amounts of carbon dioxide from a relatively small flow rate of blood. This decarboxylator device could help support patients when respirators fail to remove sufficient C02, or be used in place of respirators in patients with moderate C02 retention. The decarboxylator system will be created by developing a new disposable package for the BioLogic dialysis machine. This machine is design to perform dialysis through a single blood access (subclavian catheter or needle) using a plate dialyzer both for chemical clearance and for pumping blood. We will design a disposable package (DC pack) with a suspension of calcium hydroxyl which will move through a screen plate dialyzer in a to-and-fro manner to maintain fluidity. Within the dialyzer, the calcium hydroxide will exchange its hydroxyl for bicarbonate, removing almost all of the blood bicarbonate without excessive calcium or hydroxyl return to the blood. In vitro tests during Phase I will determine the CO2 removal rate, calcium return, and pH changes caused by the BioLogic-DC system. These studies will indicate whether the system has potential for assisting patients in respiratory failure.

本项目的目标是开发一种体外装置， 从相对较小的流量中去除大量的二氧化碳 血的速度。 这个脱羧装置可以帮助 当呼吸机不能去除足够的CO2时， 在中度CO2潴留的患者中代替呼吸机。 脱羧系统将通过开发一种新的 BioLogic透析机的一次性包装。 这台机器 设计成通过单个血液通路进行透析 （锁骨下导管或针）使用平板透析器， 化学清除和泵血。 我们将设计一 含有羟基钙悬浮液的一次性包装（DC包装） 其将以往复的方式移动通过筛板透析器 保持流动性的方式。 在透析器中，钙 氢氧化物将其羟基交换为碳酸氢盐， 几乎所有的血液碳酸氢盐没有过多的钙或 羟基回到血液中。 第一阶段的体外试验将 确定CO2去除率、钙返回和pH变化 是由BioLogic-DC系统引起的 这些研究表明， 该系统是否有潜力帮助患者 呼吸衰竭