LASERS IN THE TREATMENT OF FETAL HEART DISEASE

激光治疗胎儿心脏病

• 批准号: 2715390
• 负责人: BARBARA Ann SOLTZ
• 金额: $ 9.98万
• 依托单位: CONVERSION ENERGY ENTERPRISES
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 2000-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2715390
• 关键词: biomedical equipment development; clinical biomedical equipment; embryo /fetus disorder; heart disorder; heart surgery; hemostasis; laser therapy; method development; physiologic anastomosis; tissue /cell culture

DESCRIPTION (Adapted from applicant's abstract): Congenital heart defects may be caused by a single, simple malformation which produces severe secondary problems. By operating on the fetus, these secondary problems may be avoided. However, fetal tissues are far more fragile than postnatally, and conventional surgical approaches cannot be used as the sutures pull through the tissues. Providing a hemostatic and strong bond between tissues by using laser welding technology may allow repairs to be made thereby making fetal cardiac surgery a reality. Further, laser assisted hemostasis will prevent hemorrhage which will be a major risk factor to the fetus. By comparing conventionally sutured anastomoses to laser assisted or laser welded anastomoses, the strength and fluid integrity of the weld will be defined. The validity of laser technology for fetal vascular anastomotic applications will be determined. Phase I feasibility studies will include both in vitro and in vivo experiments. Spectroscopic measurement on fetal tissue will guide the selection of laser wavelength. Both temperature and optical feedback methods will be explored for controlling the laser in order to produce strong tissue bonds. Tissue solders will be evaluated to enhance tissue welding and hemostasis. In Phase II, sensor control of the laser, based on a tissue signature change at the welding endpoint, will be designed and developed, specifically for this application. PROPOSED COMMERCIAL APPLICATION: The development of fetal vascular anastomotic procedures using laser welding technology may be applicable to heart bypass surgery in adults, emergency would closure and hemostasis.

描述（改编自申请人摘要）：先天性心脏病 缺陷可能由单一的、简单的畸形引起， 严重的次要问题。 通过对胎儿进行手术， 可以避免问题。 然而，胎儿组织要脆弱得多， 传统的手术方法不能用于 因为缝合线会穿过组织 提供止血剂， 通过使用激光焊接技术，组织之间的强结合可以允许 从而使胎儿心脏手术成为现实。 此外，激光辅助止血将防止出血， 对胎儿来说是一个主要的危险因素。 通过传统的比较 缝合的人工关节到激光辅助或激光焊接的人工关节， 将定义焊接的强度和流体完整性。 有效性 激光技术在胎儿血管吻合中的应用 测定 第一阶段可行性研究将包括体外和 体内实验。 对胎儿组织的光谱测量将 指导激光波长的选择。 温度和光学 将探索用于控制激光器的反馈方法，以便 产生牢固的组织粘合。 将对组织焊料进行评价， 增强组织焊接和止血。 在第二阶段， 所述激光器基于焊接终点处的组织特征变化， 将专门针对这一应用进行设计和开发。 拟定商业应用： 激光胎儿血管吻合术的进展 焊接技术可应用于成人的心脏旁路手术， 紧急缝合止血。