Laser Activated Ophthalmic Adhesive

激光激活眼科粘合剂

• 批准号: 7472807
• 负责人: BARBARA Ann SOLTZ
• 金额: $ 7.15万
• 依托单位: CONVERSION ENERGY ENTERPRISES
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2009-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7472807
• 关键词: Adhesions; Adhesives; Anastomosis - action; Animal Experiments; Animal Model; Animals; Area; Biocompatible Materials; Biodegradation; Blindness; Blood Vessels; Blunt Trauma; Bulla; Cataract; Cataract Extraction; Chemistry; Clinical; Clinical Trials; Closure; Collagen; Conjunctival Pterygium; Cornea; Corneal Injury; Corneal Ulcer; Cross-Linking Reagents; Cyanoacrylates; Data; Development; Doctor of Philosophy; Drug Formulations; End Point; Ensure; Excision; Extracapsular; Eye; Eye diseases; Film; Foundations; Funding; Glaucoma; Glues; Goals; Grant; Human; Impairment; In Situ; In Vitro; Institutes; Investigation; Keratoplasty; Laboratory Research; Laceration; Lamellar Keratoplasty; Laser In Situ Keratomileusis; Lasers; Lead; Measures; Mechanics; Medical Electronics; Membrane; Methods; Modeling; National Eye Institute; Object Attachment; Operative Surgical Procedures; Outcome; Penetrating Keratoplasty; Phase; Phase I Clinical Trials; Phase II Clinical Trials; Postoperative Period; Preparation; Principal Investigator; Procedures; Process; Property; Proteins; Psychological reinforcement; Radial Keratotomy; Rate; Reaction; Reagent; Research; Research Personnel; Retinal; Risk; Rupture; Sampling; Secure; Site; Small Business Funding Mechanisms; Small Business Innovation Research Grant; Solutions; Standards of Weights and Measures; Sterility; Sterilization for infection control; Strabismus; Surgical Flaps; Surgical Models; Surgical incisions; Surgical sutures; Survivors; System; Techniques; Technology; Temperature; Tensile Strength; Testing; Thick; Tissue Adhesives; Tissues; Trauma; United States Dept. of Health and Human Services; United States Food and Drug Administration; United States National Institutes of Health; Vision; Welding; Work; anterior chamber; articular cartilage; base; biomaterial compatibility; cell injury; commercialization; conjunctiva; corneal surgery; design; experience; improved; in vitro Model; in vivo; innovation; pre-clinical; pressure; protein crosslink; reconstruction; repaired; research study; response; seal; sensor; skills; tissue glueing; tissue soldering; tissue welding; wound

Project Summary The significance of this project is the development of a laser assisted tissue welding technique to close corneal wounds, provide a foundation for innovative treatment of eye disease and demonstrate the unique properties of a laser cured collagen adhesive to repair ophthalmic tissue with superior strength and stability. Millions of ophthalmic procedures are performed annually, most incorporating sutures to close and seal wounds. Yet this method can cause severe complications, can weaken the integrity of the eye and may pose a risk for ocular rupture in the case of blunt trauma. Other techniques to close wounds, including the use of tissue glues or grafting, can be even more problematic. Phase I studies were conducted to measure the biostability of solder formulations, evaluate tissue bonding strategies and compare wound stability as a function of intrachamber pressure in four in vitro models of clinical corneal surgery: radial keratotomy, LASIK flaps, penetrating keratoplasty and cataract excision. The results confirmed that the laser solder approach is superior to standard sutures with no evidence of tissue shrinkage. The strength of the soldered repair was dependent upon reaching a precise temperature set by choice of laser, solder composition and film thickness. Solder biostability is increased by reaction with a standard crosslinking reagent. The specific aim for Phase II is to optimize solder processing, laser techniques and surgical outcome in survivor animal surgical models. Task descriptions include preparation of sterile solder under stringent process controls, design and assembly of a compact preclinical laser systems, optimization of a laser handpiece and perform ex vivo and in vivo experiments on a lapine model. Surgical endpoints will include the quality of the wound seal, the extent, if any, of collateral thermal tissue damage, solder stability and biocompatibility.

项目总结