BEDSIDE AUDIO VESTIBULAR TESTING SYSTEM

描述：在拟议项目的第一阶段， 床旁耳毒性听前庭筛查和测试系统 将开展监测。 抗真菌和强效抗生素 药物是救命药，但可能有显着的副作用，包括 耳毒性 一种潜在有效的限制或防止 药物引起的耳蜗和前庭功能损害， 耳毒性是监测病人在化疗期间的状态。 然而，耳毒性监测的实用、具有成本效益的方案， 目前的方法是片面的，侧重于 在内耳评估中的听力状况。 科学 匹兹堡大学研究人员在耳毒性方面的突破 与智能听力系统相结合， 基于微处理器的仪器和数字信号处理 创新现在提供了必要的技术来执行成本- 有效的床旁耳毒性监测。 原型系统将 开发将结合传统和高频失真 产品耳声发射评估和听力测试沿着头部- 只做前庭功能的旋转测试 的有效性和 将根据实验室/临床 在多个群体中进行标准测试。可探测性的极限 耳蜗和前庭功能的显著变化将是 测定 这些工作将由一个跨学科小组进行 利用最先进的技术，将可行的产品， 市场 拟议商业应用：不可用

DESCRIPTION: In Phase I of the proposed project, an integrated audiovestibular screening and testing system for bedside ototoxicity monitoring will be developed. Antineoplastic and powerful antibiotic drugs are life-savers but can have significant side effects, including ototoxicity. A potentially effective way of limiting or preventing functional impairment from drug-induced cochleo- and vestibulo- ototoxicity is to monitor the patient's status during chemotherapy. Practical, cost-effective programs of ototoxicity monitoring, however, have yet to be developed and current approaches are one-sided, focusing on hearing status in their evaluation of the inner ear. Scientific breakthroughs by University of Pittsburgh researchers on ototoxicity monitoring, in conjunction with Intelligent Hearing Systems' microprocessor-based instrumentation and digital signal processing innovations now provide the necessary technology to perform cost- effective, bedside ototoxicity monitoring. The prototype system to be developed will incorporate conventional and high-frequency distortion product otacoustic emissions assessment and audiometry along with head- only rotational testing of vestibular function. The validity and reliability of the device will be assessed against laboratory/clinical standard tests in multiple populations. The limits of detectability of significant changes in cochlear and vestibular function will be determined. These efforts will be pursued by an interdisciplinary team utilizing state-of-the-art technology to bring a viable product to market. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE