BEDSIDE AUDIO VESTIBULAR TESTING SYSTEM FOR OTOTOXICITY

本阶段研究的目的是开发一种客观的耳毒性床边试验，即暴露于化学制剂（通常为药物）引起的内耳损伤。 目前，容易监测听力或平衡功能丧失的能力相当有限，因此，耳毒性难以预防。 耳毒性的床旁测试组合将允许由听力和平衡方面的非专家对怀疑患有这种疾病的大组患者进行评估。 平衡测试采用仅头部旋转来刺激前庭眼反射增益，避免了昂贵和笨重的设备的需要。 听觉功能测试是测量由听觉器官的外毛细胞产生的耳声发射回声样信号，已知外毛细胞对药物耳毒性非常敏感。 床边措施进行了比较，一个全面的标准电池的实验室措施。 受试者是正常对照和接受化疗（即顺铂治疗癌症）的患者。

The objective of this phase of the study is to develop an objective bedside test of ototoxicity, i.e. damage to the inner ear caused by exposure to chemical agents, typically pharmaceutical. At the present time, the ability to easily monitor loss of hearing or balance function is quite limited and, as a result, ototoxicity is difficult to prevent. A bedside test battery for ototoxicity would allow for assessment of large groups of patients suspected of suffering from this condition by nonspecialists in hearing and balance. The test of balance employs head-only rotation to stimulate the vestibulo-ocular reflex gain, obviating the need for expensive and cumbersome equipment. The test of auditory function is the measurement of otoacoustic emission-echo-like signals generated by the outer hair cells of the hearing organ which are known to be acutely sensitive to drug ototoxicity. The bedside measures are compared with a comprehensive standard battery of laboratory measures. The subjects are both normal controls and patients undergoing chemotherapy, namely treatment of cisplatin for cancer.