BEDSIDE AUDIO VESTIBULAR TESTING SYSTEM FOR OTOTOXICITY

这一阶段研究的目标是制定一项客观的耳毒性测试，即接触化学制剂(通常是药物)对内耳造成的损害。目前，很容易监测听力或平衡功能丧失的能力相当有限，因此，耳毒性很难预防。床边的耳毒性测试电池将允许听力和平衡方面的非专家对大量疑似患有耳毒性的患者进行评估。平衡测试仅使用头部旋转来刺激前庭-眼睛反射增益，从而消除了对昂贵和笨重设备的需要。听觉功能测试是对已知对药物耳毒性非常敏感的听力器官外毛细胞产生的耳声发射-回声样信号的测量。将床边措施与全面标准的实验室措施进行比较。受试者既是正常对照组，也是正在接受化疗的患者，即接受顺铂治疗的癌症患者。

The objective of this phase of the study is to develop an objective beside test of ototoxicity, i.e. damage to the inner ear caused by exposure to chemical agents, typically pharmaceutical. At the present time, the ability to monitor easily loss of hearing or balance function is quite limited and, as a result, ototoxicity is difficult to prevent. A bedside test battery for ototoxicity would allow for assessment of large groups of patients suspected of suffering from this condition by nonspecialists in hearing and balance. The test of balance employs head-only rotation to stimulate the vestibulo-ocular reflex gain, obviating the need for expensive and cumbersome equipment. The test of auditory function is the measurement of otoacoustic emission-echo-like signals generated by the outer hair cells of the hearing organ which are known to be acutely sensitive to drug ototoxicity. The bedside measures are compared with a comprehensive standard battery of laboratory measures. The subjects are both normal controls and patients undergoing chemotherapy, namely treatment by cisplatin for cancer.