BLOOD PRESSURE CONTROL BY FOREBRAIN & BRAINSTEM NEURONS

前脑控制血压

• 批准号: 2771247
• 负责人: SUSAN M BARMAN
• 金额: $ 15.97万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-30 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2771247
• 关键词: brain electrical activity; brain mapping; brain stem; cardiovascular function; catecholamines; cats; electrophysiology; interneurons; neural information processing; neuroanatomy; neurogenic hypertension; prosencephalon; serotonin; sympathetic nervous system

DESCRIPTION: (adapted from applicant's abstract) The long-range goal of this research is to characterize the CNS pathways that control basal sympathetic nerve discharge (SND) and cardiovascular function. Since 1990, the PI has studied the control of the 10-Hz rhythm that is the predominant feature of SND in decerebrate or urethane- anesthetized cats. This rhythm is highly coherent in nerves controlling a variety of cardiovascular target organs and may be a prerequisite for inducing the complex patterns of spinal sympathetic outflow that accompany some behavioral states. Studies during the current funding period are the first to identify specific CNS sites that regulate this activity. Data from antidromic activation experiments have indicated reciprocal connections between some of these areas and pharmacologic studies have suggested neurotransmitter systems that are important in the control of the 10 hz rhythm in SND. In the proposed 5-yr research plan, state-of-the-art electrophysiologic and analytic techniques will be combined with microiontophoresis and microinjection of drugs to address 4 Specific aims: (1) To test the hypothesis that pontine neurons in the A5, A6 and parabrachial/Kolliker- Fuse complex are involved in the control of the 10 Hz rhythm, (2) To identify the interconnections and signs (excitation or inhibition) of synaptic connections among brainstem neurons with activity correlated to the 10 Hz rhythm in SND, (3) To test the hypothesis that the 10 Hz rhythm is generated by a distributed network of brainstem neurons, and (4) to identify the central sites where serotonergic and catecholaminergic neurons act to affect the balance between the 10 Hz rhythm and the irregular 2-6 Hz oscillations in SND. These studies will enhance our understanding of the central circuitry responsible for generating and controlling the 10 Hz rhythm in resting SND.

描述：（改编自申请人的摘要）长期目标 这项研究的目的是表征控制中枢神经系统通路 基础交感神经放电（SND）和心血管功能。 自 1990 年以来，PI 一直在研究 10 Hz 节律的控制， 是去大脑或聚氨酯中 SND 的主要特征 被麻醉的猫。这种节奏在神经上是高度连贯的 控制多种心血管靶器官，可能是 诱导脊髓交感神经复杂模式的先决条件 伴随某些行为状态的流出。期间学习 目前的资助期限是首先确定具体的CNS 监管此活动的网站。来自逆向激活的数据 实验表明，某些因素之间存在相互联系 这些领域和药理学研究表明神经递质 对于控制 SND 中的 10 Hz 节奏非常重要的系统。 在拟议的 5 年研究计划中，最先进的电生理学 分析技术将与微离子电渗疗法相结合 和显微注射药物以解决 4 个具体目标：（1）测试 假设 A5、A6 和臂旁/Kolliker 中的脑桥神经元 熔丝复合体参与 10 Hz 节律的控制，(2) 识别互连和信号（激发或抑制） 脑干神经元之间的突触连接与活动 与 SND 中的 10 Hz 节律相关，(3) 检验以下假设： 10 Hz 节律由脑干分布式网络产生 神经元，以及（4）识别血清素能和 儿茶酚胺能神经元的作用是影响 10 Hz 频率之间的平衡 SND 中的节律和不规则 2-6 Hz 振荡。这些研究 将增强我们对负责的中央电路的理解 用于在静息 SND 中生成和控制 10 Hz 节律。