NOVEL REAGENTS AND CATALYSTS FOR CHIRAL PHARMACEUTICALS
手性药物的新型试剂和催化剂
基本信息
- 批准号:6240025
- 负责人:
- 金额:$ 10.83万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1997
- 资助国家:美国
- 起止时间:1997-07-01 至 1998-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The project goals are to continue to develop new science at the cutting
edge of modern synthetic chemistry. The student co-investigators are
an integral part of the research process, not only through the
execution of the experimental work and in the analytical spectroscopic
evaluation and interpretation, but also, in the scientific development
process through literature seminars, presentations and publications,
procedures which assure the continued growth of knowledge, both now and
in the future. The specific research proposed herein takes full
advantage of research expertise developed in our laboratories over the
past twenty years in the general area of Main Group organometallic
reagents and reactions and their applications to the asymmetric
synthesis of simple natural products and important pharmaceuticals. The
project's focus will be directed toward the development of new
chemistry as It relates to important pharmaceutical and potentially
important natural and unnatural products. As specific studies: (1) We
have prepared an entirely new type of chiral ouzaborolane which will
be screened as a borane-based asymmetric reduction catalyst by analogy
to Corey's CBS catalysts which have been employed for the asymmetric
syntheses of Prozac, D1 antagonists, beta-agonists, prostaglandins
thromboxane A2 and other pharmaceuticals. Numerous potential
applications in the synthesis of antihypertensive drugs have been
identified. (2) Following our recent successful new asymmetric
syntheses of the chiral pheromones, frontalin and exo-brevicomin, the
Suzuki protocol will be applied to the total synthesis of alpha-
methoxylated fatty acid metabolites which have been isolated locally
from the marine sponge, Spheciospongia cusudifera. (3) A new NMR
protocol will be applied to the assay of organoborane mixtures. Also
a new chiral silane which can effectively derivatize alcohols, amines
and carboxylic acids is proposed as an effective new tool to assay the
enantiomeric excess present in synthetic products and pharmaceuticals.
(4) Our new stable isolable alkynylboranes will be examined
particularly with respect to the asymmetric synthesis of propargylic
alcohols through known CBS-type catalytic processes and with our new
catalyst. Moreover, we plan to expand the Suzuki-Miyaura protocol
developed in our laboratory to demonstrate that potential DNA-cleaving
compounds of the enediyne type can be prepared through this new
technology. (5) Our new simple method for carboxylate protection will
be applied to the protection of amino acids for applications to peptide
synthesis. (6) A number of remarkably stable silylamine derivatives
have been prepared whose chemistry will be explored as new chiral
lithium bases as a convenient entry to chiral enol ethers.
该项目的目标是继续在切割方面发展新的科学
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('JOHN A SODERQUIST', 18)}}的其他基金
NOVEL REAGENTS AND CATALYSTS FOR CHIRAL PHARMACEUTICALS
手性药物的新型试剂和催化剂
- 批准号:
6601183 - 财政年份:2002
- 资助金额:
$ 10.83万 - 项目类别:
NOVEL REAGENTS AND CATALYSTS FOR CHIRAL PHARMACEUTICALS
手性药物的新型试剂和催化剂
- 批准号:
6631250 - 财政年份:2002
- 资助金额:
$ 10.83万 - 项目类别:
NOVEL REAGENTS AND CATALYSTS FOR CHIRAL PHARMACEUTICALS
手性药物的新型试剂和催化剂
- 批准号:
6564511 - 财政年份:2002
- 资助金额:
$ 10.83万 - 项目类别:
NOVEL REAGENTS AND CATALYSTS FOR CHIRAL PHARMACEUTICALS
手性药物的新型试剂和催化剂
- 批准号:
6609859 - 财政年份:2002
- 资助金额:
$ 10.83万 - 项目类别:
NOVEL REAGENTS AND CATALYSTS FOR CHIRAL PHARMACEUTICALS
手性药物的新型试剂和催化剂
- 批准号:
6472787 - 财政年份:2001
- 资助金额:
$ 10.83万 - 项目类别:
NOVEL REAGENTS AND CATALYSTS FOR CHIRAL PHARMACEUTICALS
手性药物的新型试剂和催化剂
- 批准号:
6325846 - 财政年份:2000
- 资助金额:
$ 10.83万 - 项目类别:
NOVEL REAGENTS AND CATALYSTS FOR CHIRAL PHARMACEUTICALS
手性药物的新型试剂和催化剂
- 批准号:
6219056 - 财政年份:1999
- 资助金额:
$ 10.83万 - 项目类别:
NOVEL REAGENTS AND CATALYSTS FOR CHIRAL PHARMACEUTICALS
手性药物的新型试剂和催化剂
- 批准号:
6271547 - 财政年份:1998
- 资助金额:
$ 10.83万 - 项目类别:
NOVEL REAGENTS AND CATALYSTS FOR CHIRAL PHARMACEUTICALS
手性药物的新型试剂和催化剂
- 批准号:
6107134 - 财政年份:1998
- 资助金额:
$ 10.83万 - 项目类别:
METALLOIDS IN ASYMMETRIC AND STEREOSELECTIVE SYNTHESIS
不对称和立体选择性合成中的类金属
- 批准号:
3734270 - 财政年份:
- 资助金额:
$ 10.83万 - 项目类别:
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