To B-E or not to B-E? Developing New Boranes and Boration Reactions

生存还是毁灭?

基本信息

  • 批准号:
    RGPIN-2016-04302
  • 负责人:
  • 金额:
    $ 3.95万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Discovery Grants Program - Individual
  • 财政年份:
    2022
  • 资助国家:
    加拿大
  • 起止时间:
    2022-01-01 至 2023-12-31
  • 项目状态:
    已结题

项目摘要

The addition of boron-element (B-E, where E = H, B, Si, etc) bonds to unsaturated compounds constitutes a family of remarkably important reactions in organic synthesis for the production of new compounds for the pharmaceutical and agricultural industries. Reactions of B-E where E is a heavier main group elements (E = silicon, germanium, etc) usually result in organodimetalloid compounds which are highly versatile building blocks that are otherwise difficult to synthesize. Given the intensity of interest in this area it is somewhat surprising that relatively little is known about the analogous addition chemistry of compounds containing single B-E bonds where E is either sulfur (S), selenium (Se), or phosphorus (P). To address this limitation in boron chemistry, this proposal will focus on expanding the scope and chemistry of relatively unknown B-E (E = P, S, Se) compounds. For instance, we have recently reported a new phosphinoboronate ester (Ph2PBpin, pin = pinacolato) that can be used as a platform for the synthesis of a wide range of new compounds. Likewise, we have prepared new starting materials containing discrete B-S and B-Se bonds and propose to further investigate their addition chemistry. The first project in this study will be to generate additional B-E (E = P, S, Se) compounds, where we can electronically and sterically vary the groups on the boron atom and/or the main group element. A variety of substrates will be examined in addition reactions to assess the efficacy of these simple new boron-main group compounds. New reagents will also be investigated for their ability to react with aldehydes (and ketones) already containing a phosphide (PR2) or sulfide group (SR). The resulting products will be examined for their potential to add to metals that can be used as catalysts. We have also found that Ph2PBpin adds to phenylacetylene (PhCCH) in the presence of a metal catalyst to give an unusual 1,1-addition product. We will expand the scope of this reaction by varying the alkynes and the catalysts to see if we can generate different products. The 1,1-addition products in these reactions will subsequently be investigated as ambiphilic (containing a donor and acceptor group) ligands for transition metals. Finally, while significant advances have been made in catalytic boration chemistry, the full potential of these reagents in organic synthesis is not yet close to being realized. Finally, we propose to investigate these new B-E species for their use in the borylformylation of alkynes. The related hydroformylation is one of the most important catalytic reactions in industry today. The last project may be challenging but it has the potential to generate novel chemical reactions. As always, this work will be used to attract, and train, the next generation of Wild Toad (the name of our group) researchers who will hopefully make a considerable impact in Canadian science, technology, medicine and education.
硼元素(B-E,其中E = H、B、Si等)键与不饱和化合物的加成构成了有机合成中一类非常重要的反应,用于生产用于制药和农业工业的新化合物。 B-E的反应,其中E是较重的主族元素(E =硅、锗等),通常产生有机双金属化合物,其是高度通用的结构单元,否则难以合成。 考虑到在这一领域的兴趣强度,令人惊讶的是,关于含有单个B-E键的化合物的类似加成化学,其中E是硫(S)、硒(Se)或磷(P),相对知之甚少。 为了解决硼化学中的这种限制,本提案将集中于扩展相对未知的B-E(E = P,S,Se)化合物的范围和化学性质。 例如,我们最近报道了一种新的膦基硼酸酯(Ph 2 PBpin,pin =频哪醇合),其可用作合成多种新化合物的平台。 同样,我们已经制备了含有离散的B-S和B-Se键的新起始材料,并建议进一步研究它们的加成化学。 本研究的第一个项目将是产生额外的B-E(E = P,S,Se)化合物,在那里我们可以电子和空间上改变硼原子和/或主族元素上的基团。 各种各样的底物将被检查,此外反应,以评估这些简单的新的硼主族化合物的功效。还将研究新试剂与已经含有磷化物(PR 2)或硫化物基团(SR)的醛(和酮)反应的能力。 将检查所得产品添加到可用作催化剂的金属中的潜力。 我们还发现,在金属催化剂的存在下,Ph 2 PBpin与苯乙炔(PhCCH)加成,得到不寻常的1,1-加成产物。 我们将通过改变炔和催化剂来扩大该反应的范围,看看我们是否可以生成不同的产物。 这些反应中的1,1-加成产物随后将作为过渡金属的两亲性(含有供体和受体基团)配体进行研究。最后,虽然在催化硼化化学方面取得了重大进展,但这些试剂在有机合成中的全部潜力尚未接近实现。最后,我们建议研究这些新的B-E物种,用于炔的硼基化。 相关加氢反应是当今工业中最重要的催化反应之一。 最后一个项目可能具有挑战性,但它有可能产生新的化学反应。与往常一样,这项工作将被用来吸引和培训下一代野生蟾蜍(我们小组的名字)研究人员,他们将有望对加拿大的科学、技术、医学和教育产生相当大的影响。

项目成果

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Westcott, Stephen其他文献

Tourism and grey seals in south Devon: management strategies, voluntary controls and tourists' perceptions of disturbance
德文郡南部的旅游业和灰海豹:管理策略、自愿控制和游客对干扰的看法
  • DOI:
    10.1080/13683500802295663
  • 发表时间:
    2009-01-01
  • 期刊:
  • 影响因子:
    8
  • 作者:
    Curtin, Susanna;Richards, Steven;Westcott, Stephen
  • 通讯作者:
    Westcott, Stephen

Westcott, Stephen的其他文献

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{{ truncateString('Westcott, Stephen', 18)}}的其他基金

Green Boron Chemistry
绿色硼化学
  • 批准号:
    CRC-2018-00306
  • 财政年份:
    2022
  • 资助金额:
    $ 3.95万
  • 项目类别:
    Canada Research Chairs
Green Boron Chemistry
绿色硼化学
  • 批准号:
    CRC-2018-00306
  • 财政年份:
    2021
  • 资助金额:
    $ 3.95万
  • 项目类别:
    Canada Research Chairs
To B-E or not to B-E? Developing New Boranes and Boration Reactions
生存还是毁灭?
  • 批准号:
    RGPIN-2016-04302
  • 财政年份:
    2021
  • 资助金额:
    $ 3.95万
  • 项目类别:
    Discovery Grants Program - Individual
Green Boron Chemistry
绿色硼化学
  • 批准号:
    CRC-2018-00306
  • 财政年份:
    2020
  • 资助金额:
    $ 3.95万
  • 项目类别:
    Canada Research Chairs
To B-E or not to B-E? Developing New Boranes and Boration Reactions
生存还是毁灭?
  • 批准号:
    RGPIN-2016-04302
  • 财政年份:
    2019
  • 资助金额:
    $ 3.95万
  • 项目类别:
    Discovery Grants Program - Individual
Green Boron Chemistry
绿色硼化学
  • 批准号:
    CRC-2018-00306
  • 财政年份:
    2019
  • 资助金额:
    $ 3.95万
  • 项目类别:
    Canada Research Chairs
Green Boron Chemistry
绿色硼化学
  • 批准号:
    CRC-2018-00306
  • 财政年份:
    2018
  • 资助金额:
    $ 3.95万
  • 项目类别:
    Canada Research Chairs
Green Boron Chemistry
绿色硼化学
  • 批准号:
    1000227926-2011
  • 财政年份:
    2018
  • 资助金额:
    $ 3.95万
  • 项目类别:
    Canada Research Chairs
To B-E or not to B-E? Developing New Boranes and Boration Reactions
生存还是毁灭?
  • 批准号:
    RGPIN-2016-04302
  • 财政年份:
    2018
  • 资助金额:
    $ 3.95万
  • 项目类别:
    Discovery Grants Program - Individual
To B-E or not to B-E? Developing New Boranes and Boration Reactions
生存还是毁灭?
  • 批准号:
    RGPIN-2016-04302
  • 财政年份:
    2017
  • 资助金额:
    $ 3.95万
  • 项目类别:
    Discovery Grants Program - Individual

相似海外基金

New Opportunities in Enantioselective Catalysis Using Lewis Acidic Boranes
使用路易斯酸性硼烷进行对映选择性催化的新机遇
  • 批准号:
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生存还是毁灭?
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生存还是毁灭?
  • 批准号:
    RGPIN-2016-04302
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    2019
  • 资助金额:
    $ 3.95万
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    Discovery Grants Program - Individual
To B-E or not to B-E? Developing New Boranes and Boration Reactions
生存还是毁灭?
  • 批准号:
    RGPIN-2016-04302
  • 财政年份:
    2018
  • 资助金额:
    $ 3.95万
  • 项目类别:
    Discovery Grants Program - Individual
To B-E or not to B-E? Developing New Boranes and Boration Reactions
生存还是毁灭?
  • 批准号:
    RGPIN-2016-04302
  • 财政年份:
    2017
  • 资助金额:
    $ 3.95万
  • 项目类别:
    Discovery Grants Program - Individual
To B-E or not to B-E? Developing New Boranes and Boration Reactions
生存还是毁灭?
  • 批准号:
    RGPIN-2016-04302
  • 财政年份:
    2016
  • 资助金额:
    $ 3.95万
  • 项目类别:
    Discovery Grants Program - Individual
Expanding the Boundaries in Main Group Chemistry: New Boranes for Novel Reactivity
拓展主族化学的界限:具有新反应性的新硼烷
  • 批准号:
    EP/N02320X/1
  • 财政年份:
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  • 资助金额:
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胺硼烷作为新的拓扑异构酶 II 抑制剂
  • 批准号:
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  • 财政年份:
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