NEUROIMMUNOMODULATION PATCH CLAMP STUDIES
神经免疫调节膜片钳研究
基本信息
- 批准号:6107227
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1997
- 资助国家:美国
- 起止时间:1997-03-01 至 1999-02-28
- 项目状态:已结题
- 来源:
- 关键词:Mus musculus T lymphocyte anticholinergic agent beta adrenergic agent beta antiadrenergic agent biological signal transduction cellular immunity electrophysiology hormone regulation /control mechanism human tissue immunoregulation laboratory mouse membrane channels neurohormones neuroimmunomodulation neuropeptides neurotransmitter receptor neurotransmitters second messengers serotonin steroid hormone substance P voltage /patch clamp
项目摘要
The long-term objective of this proposal is to further our understanding
of the cellular and subcellular mechanisms underlying the process of
neuroimmunomodulation.
Evidence has accumulated to support the idea that the nervous system
interacts with the immune system. Results from anatomical, biochemical
and physiological studies all suggest an effect of neural substance,
neuropeptides, neurotransmitters and hormones, on several lymphocyte
functions.
An idea of the way these substances can modulate lymphocyte function is
based on the observation that lymphocyte activation, mitogenesis and
volume regulation are dependent on ionic fluxes, and neuropeptides and
hormones that have been shown to modulate the immune response also
modulate potassium and calcium channels in excitable cells. Thus, a
possible mechanism by which the nervous system regulates the immune
response is by modulating lymphocyte ion channels and currents. We
therefore propose to study the effects of immunologically active
transmitters, peptides and hormones on the ionic channels and currents
of lymphocytes.
The specific aims are: 1) Measure, using the whole cell configuration
of the patch clamp technique (Hamil, et al., 1981), the electrical
activity of murine and human T lymphocytes and study the modulation of
this activity by neurotransmitters, neuropeptides and hormones. 2) Assess
whether resting or proliferating T cells are more responsive to the
applied neuromodulators. 3) Determine the second messenger system
involved in the modulatory effect(s) observed.
These studies will provide relevant information for our understanding of
the signal transduction pathways involved in lymphocyte function and
regulation and the design of immunosuppressive or immunoenhancing agents
on the basis of their channel blocking properties.
这项建议的长期目标是增进我们的了解
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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AMELIA RIVERA其他文献
AMELIA RIVERA的其他文献
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{{ truncateString('AMELIA RIVERA', 18)}}的其他基金
MECHANISMS OF IMMUNOSUPPRESSION IN MODELED MICROGRAVITY
微重力模型中的免疫抑制机制
- 批准号:
7561499 - 财政年份:2007
- 资助金额:
-- - 项目类别:
MECHANISMS OF IMMUNOSUPPRESSION IN MODELED MICROGRAVITY
微重力模型中的免疫抑制机制
- 批准号:
7336001 - 财政年份:2006
- 资助金额:
-- - 项目类别:
MECHANISMS OF IMMUNOSUPPRESSION IN MODELED MICROGRAVITY
微重力模型中的免疫抑制机制
- 批准号:
7164267 - 财政年份:2005
- 资助金额:
-- - 项目类别:
CEMBRANOID INDUCED CALCIUM SIGNALING IN T LYMPHOCYTES
Cembranoid 在 T 淋巴细胞中诱导钙信号传导
- 批准号:
6973835 - 财政年份:2004
- 资助金额:
-- - 项目类别:
MODULATION OF CALCIUM MOBILIZATION IN T CELLS BY CEMBRANOIDS
Cembranoids 对 T 细胞钙动员的调节
- 批准号:
6644336 - 财政年份:2002
- 资助金额:
-- - 项目类别:
MODULATION OF CALCIUM MOBILIZATION IN T CELLS BY CEMBRANOIDS
Cembranoids 对 T 细胞钙动员的调节
- 批准号:
6341275 - 财政年份:2000
- 资助金额:
-- - 项目类别:
MODULATION OF CALCIUM MOBILIZATION IN T CELLS BY CEMBRANOIDS
Cembranoids 对 T 细胞钙动员的调节
- 批准号:
6317937 - 财政年份:1999
- 资助金额:
-- - 项目类别:
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