NATURAL HISTORY OF POSTTRANSFUSION HEPATITIS

乔治城大学正在进行一项慢性病的自然史研究 非甲非乙型肝炎。 该提案的具体目标是：制定一项议定书， 继续进行目前关于长期 输血相关非甲非乙型（NANB）肝炎的长期随访; 对所有队列成员进行年度国家死亡指数（NDI）搜索 末次随访时存活或未找到的患者;获得并编码死亡 所有新死者的证明;并收集和提取医疗信息 自上次随访以来发生的所有住院记录 为新近去世的受试者提供服务 将进行搜索以确定死亡率差异是否 感染组和对照组之间的差异将随着时间的推移而发展， 观察，如慢性肝病的持续存在所表明的 疾病 每一个幸存的成员将每年联系，并医疗 自上次随访以来发生的所有住院记录 将收集报告肝病的受试者的数据， 抽象的这些接触将确保任何可能有 通过酶筛选遗漏的，或可能新开发的，将是 鉴定

Georgetown University is conducting a natural history study of chronic non-A,non-B (NANB) hepatitis. The specific objectives of this proposal are: to develop a protocol and manual of operations for continuation of the current study on the long- term follow-up of transfusion-associated non-A,non-B (NANB) hepatitis; to conduct annual National Death Index (NDI) searches for all cohort members who were alive or not located at last follow-up; to obtain and code death certificates for all newly deceased; and to collect and abstract medical records for all hospitalizations that occurred since the last follow-up for newly deceased subjects. The searches will be conducted to determine whether a mortality difference between the infected cohort and the controls will develop with longer observation, as is suggested by the continued presence of chronic liver disease. Each surviving member will be contacted annually, and medical records for all hospitalizations that occurred since the last follow-up for those subjects who report liver disease will be collected and abstracted. The contacts will ensure that any liver disease that may have been missed through enzyme screening, or which may newly develop, will be identified.