NATURAL HISTORY OF POSTTRANSFUSION HEPATITIS

乔治城大学正在进行一项关于慢性疾病的自然历史研究。 非甲非乙型肝炎。 这项提议的具体目标是：制定一项议定书和 《操作手册》，用于继续目前对长岛的研究- 输血相关性非甲非乙型肝炎的长期随访 对所有队列成员进行年度国家死亡指数(NDI)搜索 在最后一次随访中谁还活着或没有被找到；获得并编码死亡 为所有新去世的人提供证书；并收集和提取医疗信息 自上次随访以来发生的所有住院记录 对于新死的受试者。 将进行搜索，以确定死亡率差异是否 感染人群和对照人群之间的关系将会发展得更长 观察，如慢性肝病持续存在所提示的 疾病。每年都会联系每个幸存的成员，并提供医疗服务 自上次随访以来发生的所有住院记录 对于那些报告肝病的受试者，将收集和 太抽象了。这些联系人将确保任何可能患有 被酶筛查漏掉的，或者可能新出现的，将被 已确认身份。

Georgetown University is conducting a natural history study of chronic non-A,non-B (NANB) hepatitis. The specific objectives of this proposal are: to develop a protocol and manual of operations for continuation of the current study on the long- term follow-up of transfusion-associated non-A,non-B (NANB) hepatitis; to conduct annual National Death Index (NDI) searches for all cohort members who were alive or not located at last follow-up; to obtain and code death certificates for all newly deceased; and to collect and abstract medical records for all hospitalizations that occurred since the last follow-up for newly deceased subjects. The searches will be conducted to determine whether a mortality difference between the infected cohort and the controls will develop with longer observation, as is suggested by the continued presence of chronic liver disease. Each surviving member will be contacted annually, and medical records for all hospitalizations that occurred since the last follow-up for those subjects who report liver disease will be collected and abstracted. The contacts will ensure that any liver disease that may have been missed through enzyme screening, or which may newly develop, will be identified.