COMMUNITY AND COHORT SURVEILLANCE PROGRAM

社区和群体监测计划

• 批准号: 2593811
• 负责人: LOUIS C. SMITH
• 金额: $ 17.04万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-01 至 1999-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2593811
• 关键词: adult human (21+); apolipoproteins; atherosclerosis; blood lipid; blood lipoprotein; cardiovascular disorder epidemiology; cholesterol; coronary disorder; diabetes mellitus; disease /disorder proneness /risk; hemostasis; human subject; medical records; myocardial infarction; ultrasonography

ARIC is a large-scale, long-term program that will measure associations of established and suspected coronary heart disease risk factors (CHD) with both atherosclerosis and new CHD events such as myocardial infarction in men and women from four diverse communities. The project has two components: community surveillance of morbidity and mortality, and repeated examinations of a representative cohort of men and women in each community. The community surveillance involves abstracting hospital records and death certificates and investigating out-of- hospital deaths. The representative cohorts include 4,000 persons from each community. Three of these reflect the ethnic composition of the communities in which they live; one cohort is black. All cohort participants are examined four times (1987-90), and 1990-93, 1993-96, and 1996-99), and contacted annually to update their medical histories. Atherosclerosis is measured by carotid and ultrasonography. Arteriosclerosis is measured using retinal photography. Cerebrovascular disease is assessed using MRI in a sample of black and white participants. Rick factors studied include: blood lipids, lipoprotein cholesterols, and apolipoproteins; plasma hemostatic factors; diabetes and glucose intolerance; blood chemistries and hematology and indicators and infectious and inflammatory disease; DNA markers of these risk factors; sitting, supine and standing blood pressures to track the development of hypertension; anthropometry; fasting blood glucose and insulin level as predictors of diabetes; ECG findings; heart rate variability; cigarette and alcohol use; physical activity level; dietary aspects; and family history. The diverse communities can be compared with respect to CHD incidence and medical care and, through the cohort component, with respect to risk factors and peripheral atherosclerosis. The results will provide a measure of the variation in the distribution and determinants of CHD in the U.S. and, within the limits of ecologic analysis, suggest possible reasons for observed differences. The contractor serves as the Central Lipid Laboratory for the ARIC. Duties include performing lipid measurements, including total cholesterol, high density lipoprotein cholesterol, triglycerides, and glucose on samples from all participants under study by the Field Centers.

ARIC 是一项大规模、长期的计划，旨在衡量关联性 已确定和可疑的冠心病危险因素 (CHD) 伴有动脉粥样硬化和新的冠心病事件，例如心肌病 来自四个不同社区的男性和女性的梗塞。项目 有两个组成部分：发病率和死亡率的社区监测， 对具有代表性的男性和女性群体进行重复检查 在每个社区。社区监控涉及抽象 医院记录和死亡证明并进行调查 医院死亡。代表性群体包括 4,000 名来自 每个社区。其中三项反映了该地区的民族构成 他们居住的社区；其中一组是黑人。 所有队列参与者均接受四次检查（1987-90 年）和 1990-93 年， 1993-96 和 1996-99），并每年联系以更新他们的医疗状况 历史。动脉粥样硬化通过颈动脉和超声检查来测量。 动脉硬化是通过视网膜摄影来测量的。脑血管 使用 MRI 对黑白样本进行疾病评估 参与者。瑞克研究的因素包括：血脂、脂蛋白 胆固醇和载脂蛋白；血浆止血因子；糖尿病 和葡萄糖不耐受；血液化学和血液学及指标 以及传染性和炎症性疾病；这些风险的 DNA 标记 因素；坐位、仰卧位和站立位血压以追踪 高血压的发展；人体测量学；空腹血糖和 胰岛素水平作为糖尿病的预测因子；心电图检查结果；心率 可变性；吸烟和饮酒；身体活动水平；饮食 方面；和家族史。 可以比较不同社区的冠心病发病率 和医疗保健，以及通过队列组成部分，关于风险 因素与外周动脉粥样硬化。结果将提供一个 测量 CHD 的分布变化和决定因素 美国并在生态分析的范围内提出了可能的 观察到的差异的原因。 承包商担任 ARIC 的中央脂质实验室。 职责包括进行血脂测量，包括总血脂测量 胆固醇、高密度脂蛋白胆固醇、甘油三酯和 该领域研究的所有参与者样本中的葡萄糖 中心。