The function and misfunction of serum apolipoproteins: lipid binding and protein misfolding.

血清载脂蛋白的功能和错误功能：脂质结合和蛋白质错误折叠。

• 批准号: FT140100544
• 负责人: A/Prof Michael Griffin
• 金额: $ 53.25万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-06-30 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT140100544
• 关键词: function; misfunction; serum; apolipoproteins; lipid

The interaction between proteins and lipids is a fundamental aspect of cellular processes in all organisms. Lipid binding proteins must be structurally dynamic to perform their function, which predisposes them to misfolding and aggregation. This project aims to assess the structural mechanisms of lipid binding by apolipoproteins, and how these proteins balance this function with their propensity to misfold. It will focus on apolipoprotein (apo)A-I as a model serum apolipoprotein that binds lipids and mediates lipid transport in circulation. This project also aims to provide an important new understanding of protein-lipid interactions, the structural mechanisms of apolipoproteins, and the process of misfolding in a diverse range of proteins.

蛋白质和脂质之间的相互作用是所有生物体中细胞过程的基本方面。脂质结合蛋白必须是结构动态的以执行它们的功能，这使它们易于错误折叠和聚集。该项目旨在评估载脂蛋白与脂质结合的结构机制，以及这些蛋白质如何平衡这种功能与其错误折叠的倾向。它将侧重于载脂蛋白（载脂蛋白）A-I作为模型血清载脂蛋白，结合脂质和介导的脂质运输循环。该项目还旨在为蛋白质-脂质相互作用，载脂蛋白的结构机制以及各种蛋白质中错误折叠的过程提供重要的新认识。