EPIDEMIOLOGY OF BREAST CANCER ON LONG ISLAND

长岛乳腺癌流行病学

• 批准号: 2712686
• 负责人: STEVEN D STELLMAN
• 金额: $ 40.04万
• 依托单位: INSTITUTE FOR CANCER PREVENTION
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-05-01 至 2000-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2712686
• 关键词: adipose tissue; age difference; body composition; breast neoplasms; cancer risk; clinical research; estrogens; female; halobiphenyl /halotriphenyl compound; halocarbon compound; human mortality; human subject; interview; neoplasm /cancer epidemiology; neoplasm /cancer relapse /recurrence; serology /serodiagnosis; women's health

DESCRIPTION: There are conflicting data regarding the associations between serum levels of OCCs (e.g., DDE) and of PCB with the risk of developing breast cancer. The application is intended to complete a previously-supported, case-control study to determine whether the levels of these substances is elevated in the serum and adipose tissue of breast cancer cases, diagnosed on Long Island, compared to controls from the same location (benign breast disease and surgical controls). To date, 338 case patients, 418 women with benign breast disease and 197 surgical controls have been interviewed, and 819 adipose samples and 896 serum aliquots collected. One fourth of these samples have been analyzed and the preliminary results show that DDE and possibly certain PCB congeners are associated with increased risk of breast cancer. The future plan is to continue in order to: 1) complete assays on the remaining 3/4 of the samples; 2) determine the lipid-adjusted serum concentrations of OCCs and their partition between serum and adipose tissue; 3) correlate OCC levels with age, body mass, and location in order to adjust breast cancer risk for these confounders; 4) determine whether adjusted risk estimates differ by estrogen receptor status of the tumors; 5) correlate OCC levels with recurrence and mortality from breast cancer via follow-up cases; 6) study short term (1-3 yr.) stability of serum OCC and PCB levels and the impact of treatment on these levels; 7) estimate breast cancer risk, utilizing different classifications for PCB congeners; and 8) determine whether OCC-related risk of breast cancer can be correlated with degrees of atypia of the benign breast biopsy controls, using pathologic reviews of samples from over 400 patients.

描述：关于以下之间的关联存在相互冲突的数据： OCC的血清水平（例如，DDE）和多氯联苯的风险， 乳腺癌 申请书旨在填写一份 先前支持的病例对照研究，以确定 这些物质在血清和乳腺脂肪组织中升高 在长岛诊断的癌症病例与来自同一地区的对照组相比， 位置（良性乳腺疾病和手术控制）。 迄今为止，338起案件 418例良性乳腺疾病患者和197例手术对照 819份脂肪样本和896份血清样本 收集。 其中四分之一的样本已被分析， 初步结果表明，DDE和可能的某些PCB同系物是 与乳腺癌风险增加有关。 未来的计划是 继续进行，以便：1）完成剩余3/4的分析 样本; 2）确定OCC的脂质调整血清浓度， 它们在血清和脂肪组织之间的分配; 3）与OCC水平相关 年龄、体重和位置，以调整乳腺癌的风险， 这些混杂因素; 4）确定调整后的风险估计是否存在差异， 肿瘤的雌激素受体状态; 5）将OCC水平与 通过随访病例的乳腺癌复发率和死亡率; 6）研究 短期（1-3年）血清OCC和PCB水平的稳定性以及 7）估计乳腺癌的风险，利用 多氯联苯同系物的不同分类;以及8）确定 OCC相关的乳腺癌风险可能与乳腺癌的程度相关 使用样本的病理审查，对良性乳腺活检对照进行分析 超过400名患者。