Agent Orange and Adverse Birth Outcomes - A Re-Examination

橙剂与不良分娩结果——重新审视

• 批准号: 9564167
• 负责人: STEVEN D STELLMAN
• 金额: $ 5.5万
• 依托单位: FOUNDATION FOR WORKER/VETERAN/ENVIR/HLTH
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-12 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9564167
• 关键词: 2,4-Dichlorophenoxyacetic Acid; Address; Archives; Area; Biological Models; Birth; Centers for Disease Control and Prevention (U.S.); Chemicals; Chlorinated Hydrocarbons; Classification; Code; Cohort Studies; Computer software; Congenital Abnormality; Contracts; Country; Data; Data Element; Data Set; Data Sources; Development; Dioxins; Dose; Environment; Event; Exposure to; Fathers; Feasibility Studies; Funding; Genetic; Health; Herbicides; Individual; Institute of Medicine (U.S.); Knowledge; Length; Location; Long-Term Effects; Methodology; Military Personnel; Mission; Modeling; Outcome; Patient Self-Report; Persons; Population; Pregnancy; Publishing; Records; Reporting; Research Personnel; Risk; Risk Estimate; Role; Route; Services; Source; Study Subject; System; Tetrachlorodibenzodioxin; Time; Uncertainty; United States; United States National Academy of Sciences; Update; Veterans; Vietnam; War; Work; agent orange; base; cohort; college; data warehouse; epidemiology study; exhaustion; experience; member; repository; reproductive; secondary analysis; software systems; sound; vector

Project Summary/Abstract Agent Orange and Adverse Birth Outcomes – A Re-Examination The possibility that the military herbicide Agent Orange caused birth defects in US veterans of the Vietnam War was the subject of two controversial CDC studies in the 1980s and of a number of subsequent studies of US veterans and in the Vietnamese population, some of whose findings have also been questioned. One component of Agent Orange, 2,4-D, continues to be used today and its use is expected to expand. A major source of uncertainty in previous studies is substantial misclassification of exposure due to lack of sound models and accurate exposure data, frequently based on self-report. Under the sponsorship of the National Academy of Sciences we have developed a rigorous and objective exposure assessment system that combines updated and accurate herbicide spray records with extensive military unit location data within an automated GIS system that we also developed. We will apply this methodology to re-assessment of possible relationships between Agent Orange exposure and birth defects in the two CDC studies.

项目概要/摘要 橙剂与不良分娩结果——重新审视 军用除草剂橙剂可能导致美国出生缺陷 越南战争退伍军人是美国疾病预防控制中心两项有争议研究的主题 20 世纪 80 年代以及随后对美国退伍军人和越南退伍军人进行的一系列研究 人口，其中一些研究结果也受到质疑。的一个组成部分 橙剂 2,4-D 至今仍在使用，预计其使用范围还会扩大。一个 先前研究中不确定性的主要来源是严重错误分类 由于缺乏合理的模型和准确的暴露数据而导致的暴露，通常基于 自我报告。在美国国家科学院的资助下，我们 开发了严格、客观的暴露评估系统，该系统结合了 利用大量军事单位位置数据更新和准确的除草剂喷洒记录 在我们还开发的自动化 GIS 系统中。我们将应用这种方法 重新评估橙剂暴露与出生之间可能存在的关系 CDC 的两项研究存在缺陷。