Agent Orange and Adverse Birth Outcomes - A Re-Examination

项目总结/摘要 橙子剂与不良出生结局--重新审视 军用除草剂橙子在美国造成出生缺陷的可能性 越南战争的退伍军人是两个有争议的疾病预防控制中心研究的主题， 20世纪80年代以及随后对美国退伍军人和越南人的一些研究 他们的一些调查结果也受到了质疑。的一个组成部分 橙子剂，2，4-D，今天继续使用，其用途预计将扩大。一 在以前的研究中，不确定性的主要来源是大量的错误分类， 由于缺乏健全的模型和准确的暴露数据， 自我报告。在国家科学院的赞助下， 开发了一个严格而客观的暴露评估系统， 更新和准确的除草剂喷洒记录，包括大量军事单位位置数据 在我们开发的自动化地理信息系统中。我们将采用这种方法 重新评估接触橙子剂与出生之间的可能关系 两项CDC研究的缺陷。

Project Summary/Abstract Agent Orange and Adverse Birth Outcomes – A Re-Examination The possibility that the military herbicide Agent Orange caused birth defects in US veterans of the Vietnam War was the subject of two controversial CDC studies in the 1980s and of a number of subsequent studies of US veterans and in the Vietnamese population, some of whose findings have also been questioned. One component of Agent Orange, 2,4-D, continues to be used today and its use is expected to expand. A major source of uncertainty in previous studies is substantial misclassification of exposure due to lack of sound models and accurate exposure data, frequently based on self-report. Under the sponsorship of the National Academy of Sciences we have developed a rigorous and objective exposure assessment system that combines updated and accurate herbicide spray records with extensive military unit location data within an automated GIS system that we also developed. We will apply this methodology to re-assessment of possible relationships between Agent Orange exposure and birth defects in the two CDC studies.