Immune-imprinting nanoparticles (iNPs)

免疫印记纳米颗粒 (iNP)

• 批准号: DP150101058
• 负责人: Prof Cordelia Selomulya
• 金额: $ 30.62万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-02-10 至 2020-05-26
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150101058
• 关键词: Immune; imprinting; nanoparticles; iNPs

This research promises new classes of immune-imprinting, biodegradable nanoparticles (iNPs) with anti-inflammatory properties. The engineering of such particles requires fundamental understanding of their properties that enable specific cellular interactions to regulate immunity with new anti-inflammatory pathways. For pulmonary delivery, spray-dried amino acid microspheres with tailored surfaces as carriers can be generated using the innovative microfluidic drying approach. The potential applications of iNPs are wide-ranging and are not restricted to pulmonary targeting. The potential commercial implications for Australia's emerging biopharmaceutical industry are substantial.

这项研究有望开发出具有抗炎特性的新型免疫印迹、可生物降解的纳米颗粒（iNP）。这些颗粒的工程需要对其特性的基本理解，这些特性使特定的细胞相互作用能够通过新的抗炎途径调节免疫力。对于肺部递送，可以使用创新的微流体干燥方法生成具有定制表面作为载体的喷雾干燥的氨基酸微球。iNP的潜在应用是广泛的，并且不限于肺部靶向。对澳大利亚新兴的生物制药行业的潜在商业影响是巨大的。