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MODULATION OF MUCOSAL RESPONSES TO HIV GP160 BY IL-12

MODULATION OF MUCOSAL RESPONSES TO HIV GP160 BY IL-12
IL-12 对 HIV GP160 的粘膜反应的调节
批准号：
2657346
负责人：
MARK A MILLER
金额：
$3.84万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-03-01 至 1998-08-31
来源：
https://reporter.nih.gov/project-details/2657346
关键词：
HIV envelope protein gp160 active immunization enzyme linked immunosorbent assay gene therapy immunomodulators in situ hybridization interleukin 12 laboratory mouse microorganism immunology mucosal immunity polymerase chain reaction recombinant proteins

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DESCRIPTION: The applicant will thoroughly characterize the murine mucosal and systemic responses (cellular and humoral) generated by immunization with HIV envelope protein, and the effectiveness of IL-12 as an adjuvant for the production of immunity at mucosal surfaces will also be examined. In Aim 1, the ability to enhance mucosal immunity by co-administering recombinant IL-12 with HIV gp160 via the oral and intranasal route will be assessed. In Aim 2, DNA IL-12 will be delivered either mucosally or remotely by IM or gene gun, and similar characterizations of immune responses will be performed. In Aim 3, experiments will examine the potential dysregulation of mucosal immune responses by immunization with rgp160 in combination with IL-12 protein or the plasmid DNA-IL-12.
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