ADOLESCENT MEDICINE HIV/AIDS RESEARCH NETWORK

青少年和年轻人中艾滋病毒/艾滋病发病率的上升 美国的人口令人震惊。 冒险行为 与这一发展时期相关联的， 通过药物滥用，多个性伴侣，同时发生性行为 传播疾病，在某些情况下，性虐待。 在孟菲斯， 在周边地区，青少年人数迅速增加， 通过这些途径感染。 艾滋病毒/艾滋病 孟菲斯的青少年人口是女性和非洲裔美国人。 他们 通过异性性接触感染，大多数情况下是与老年人接触。 艾滋病毒感染者。 这些联系往往导致怀孕。的 青少年中有关艾滋病毒/艾滋病的信息相对缺乏， 感染的生物学行为，对生长和发育的影响， 在制定治疗方案和确保 在这一人群中设计临床试验 难 因此，开发更多信息势在必行 一个科学合理的、有意义的研究议程。 St. Jude 儿童研究医院（SJCRH）是一个理想的网站， 科学中心在青少年医学艾滋病毒/艾滋病研究网络。 这是一个大型研究中心，完全致力于研究 自1962年以来，儿童和青少年的疾病。 这 这些机构为入学的青少年提供了全面的照顾 机构制药和儿科艾滋病临床试验 自1988年以来，ACTG组赞助的方案。 使用的模型 我们的艾滋病毒/艾滋病项目的综合癌症中心， 机构内有专家小组， 参与我们的病人护理。 在我们的诊所里， 通过我们与其他临床研究中心的持续合作， 孟菲斯地区，包括县和州卫生部门，成人 艾滋病护理提供者和孟菲斯艾滋病联盟， 为这一地区大多数感染艾滋病毒的青少年提供服务， 以及成功进行临床试验的能力 研究工作。 此外，SJCRH还能够提供 为支持研究议程作出重大科学贡献 在未来的努力，特别是在药理学领域。

The rising incidence of HIV/AIDS in the adolescent and young adult population in the United States is alarming. Risk-taking behaviors associated with this developmental period contribute to the increase via drug abuse, multiple sexual partners, concurrent sexually transmitted diseases, and in some cases, sexual abuse. In Memphis and the surrounding area, a rapid increase in the number of adolescents infected via these routes is occurring. Overwhelmingly the HIV/AIDS adolescent population in Memphis is female and African-American. They have become infected via heterosexual contact, most often with older HIV-infected men. Often these liaisons result in pregnancy. The relative lack of information about HIV/AIDS in adolescents, including biologic behavior of the infection, effects on growth and development, and unique problems in developing treatment regimens and insuring compliance has made designing clinical trials in this population difficult. Therefore, additional information is imperative to develop a scientifically sound, meaningful research agenda. St. Jude Children's Research Hospital (SJCRH) is an ideal site for a clinical science center in the adolescent medicine HIV/AIDS research network. It is a large research center devoted totally to the investigation of catastrophic disease of children and adolescents since 1962. This institution has provided comprehensive care for adolescents enrolled on institutional pharmaceutical, and pediatric AIDS clinical trials group (ACTG)-sponsored protocols since 1988. Using the model of the comprehensive cancer center for our HIV/AIDS program, many disciplines and subspecialists are available within the institution and actively participate in the care of our patients. Within our clinic and through our ongoing collaboration with other clinical sites within the Memphis area, including the county and state health departments, adult HIV/AIDS care providers, and the Memphis AIDS consortium, we have access to the majority of HIV-infected adolescents in this area as well as the proven capabilities for successful conduct of clinical research efforts. In addition, SJCRH is also capable of providing significant scientific contributions to support the research agenda of this effort in the future, notably in the areas of pharmacology.