St. Jude-Memphis Adolescent Trials Unit

美国青少年和年轻人中艾滋病毒/艾滋病发病率的上升， 令人担忧。据估计，美国25% -50%的新病例发生在年轻人中。孟菲斯和 周边地区也不例外，其南部位置和大量少数民族人口也 影响了病例的迅速增加。在青少年中成功进行临床试验需要一个研究中心 提供全面的医疗服务，富有同情心和关心的工作人员，个案管理服务， 友好的诊所环境和对杂费的支持。St. Jude Children's Research Hospital（SJCRH） 大型研究中心，为艾滋病毒感染的婴儿、儿童、青少年， 自1988年以来，在临床试验中表现出色， 青少年人口。我们建议在田纳西大学（UT）/卫理公会一个替代的实践地点 LeBonheur Health Systems（MLHS）。MLHS是UT的一般青少年诊所和MAYAH， 社区瑞安白色，标题四，青年服务计划。该备用研究中心将由St. Jude ATN提供工作人员 人员和恭维的主要研究单位在确定，招聘，并进行试验， HIV高危但未感染的青少年。这种模式涉及许多社区教育，外展， 这些设施将是开展社区绘图和疫苗准备研究的关键。的 该项目的具体目标是：1）建立一个有效的青少年临床试验单位， 通过招募和留住艾滋病毒感染者和 未感染艾滋病毒的高危青少年、青少年和年轻人进入生物医学和行为临床 （2）进一步发展现有的社区联系，以有效地建立一个以社区为基础的初级 支持艾滋病毒预防工作（包括疫苗）临床试验的预防基础设施，以及 其他生物医学模式;以及3）为青少年试验网络的科学议程做出贡献 通过研究者和研究中心工作人员参与制定方案概念表 和协议。孟菲斯的ATU将提供一个既有生产力， 临床研究中心邻近大量高危人群，以最大限度地实现研究 在青少年人口中的努力。

The rising incidence of HIV/AIDS in the adolescent and young adult population in the United States is alarming. It is now estimated that 25% - 50 % of new cases in the U.S. are occurring in youth. Memphis and the surrounding area are no exception and its Southern location and large minority population has also impacted the rapid increase in cases. The successful conduct of clinical trials in adolescents requires a site with comprehensive medical services, compassionate and interested staff, case management services, a friendly clinic environment, and support for incidentals. St. Jude Children's Research Hospital (SJCRH) is a large research center that has provided comprehensive care for HIV-infected infants, children, adolescents, and pregnant women since 1988 with demonstrated excellence in clinical trials performance in the adolescent population. We propose an alternate practice site at the University of Tennessee (UT)/Methodist LeBonheur Health Systems (MLHS). MLHS is the site for UT's General Adolescent Clinics and MAYAH, the community Ryan White, Title IV, Youth Services Program. This alternate site will be staffed by St. Jude ATN personnel and compliment the main research unit in the identification, recruitment, and conduct of trials in HIV-at risk but uninfected adolescents. This model engages many community education, outreach, and testing facilities that will be key in implementing community mapping and vaccine preparedness studies. The specific aims of this project are: 1) To establish an effective adolescent clinical trials unit to further the scientific agenda of the Adolescent Trials Network through the recruitment and retention of HIV-infected and at-risk HIV-uninfected pre-adolescents, adolescents, and young adults into biomedical and behavioral clinical trials; 2) To further develop existing community linkages to effectively establish a community-based primary prevention infrastructure that will support clinical trials of HIV prevention efforts, including vaccines, and other biomedical modalities; and 3) To contribute to the scientific agenda of the Adolescent Trials Network through the participation of investigators and site personnel in the development of protocol concept sheets and protocols. An ATU in Memphis would offer the combined advantages of an established, productive clinical research center with the proximity of a large at-risk population to maximize realization of the research efforts in the adolescent population.