St. Jude-Memphis Adolescent Trials Unit

美国青少年和青壮年人口中艾滋病毒/艾滋病发病率上升的原因是 令人震惊。据估计，美国25%-50%的新病例发生在年轻人中。孟菲斯和 周边地区也不例外，其南方位置和庞大的少数民族人口也是如此 影响了病例的快速增长。在青少年中成功地进行临床试验需要一个场地 拥有全面的医疗服务、富有同情心和关心的工作人员、病例管理服务、 友好的诊所环境，以及对杂费的支持。圣犹大儿童研究医院是一家 大型研究中心，为感染艾滋病毒的婴儿、儿童、青少年提供全面护理， 以及自1988年以来在临床试验中表现出色的孕妇 青少年人口。我们建议在田纳西大学(UT)/卫理公会大学设立另一个实习地点 LeBonheur Health Systems(MLHS)。MLHS是德克萨斯大学普通青少年诊所和Mayah， 社区瑞安·怀特，标题四，青年服务计划。这个备用站点的工作人员将是圣犹大ATN 并赞扬主要研究单位在确定、征聘和进行#年试验方面的工作。 艾滋病毒--处于危险之中但未受感染的青少年。此模式涉及许多社区教育、外展和 测试设施将是实施社区测绘和疫苗准备研究的关键。这个 该项目的具体目标是：1)建立一个有效的青少年临床试验单位，以促进 青少年试验网络通过招募和保留艾滋病毒感染者和妇女的科学议程 高危HIV-未感染的青少年前期、青少年和年轻人进入生物医学和行为临床 试验；2)进一步发展现有的社区联系，有效地建立以社区为基础的小学 预防基础设施，将支持艾滋病毒预防工作的临床试验，包括疫苗，以及 其他生物医学模式；以及3)为青少年试验网络的科学议程作出贡献 通过调查人员和现场人员参与制定协议概念表 和协议。孟菲斯的ATU将提供成熟、多产的综合优势 接近大量高危人群的临床研究中心，以最大限度地实现研究 在青少年人口中的努力。

The rising incidence of HIV/AIDS in the adolescent and young adult population in the United States is alarming. It is now estimated that 25% - 50 % of new cases in the U.S. are occurring in youth. Memphis and the surrounding area are no exception and its Southern location and large minority population has also impacted the rapid increase in cases. The successful conduct of clinical trials in adolescents requires a site with comprehensive medical services, compassionate and interested staff, case management services, a friendly clinic environment, and support for incidentals. St. Jude Children's Research Hospital (SJCRH) is a large research center that has provided comprehensive care for HIV-infected infants, children, adolescents, and pregnant women since 1988 with demonstrated excellence in clinical trials performance in the adolescent population. We propose an alternate practice site at the University of Tennessee (UT)/Methodist LeBonheur Health Systems (MLHS). MLHS is the site for UT's General Adolescent Clinics and MAYAH, the community Ryan White, Title IV, Youth Services Program. This alternate site will be staffed by St. Jude ATN personnel and compliment the main research unit in the identification, recruitment, and conduct of trials in HIV-at risk but uninfected adolescents. This model engages many community education, outreach, and testing facilities that will be key in implementing community mapping and vaccine preparedness studies. The specific aims of this project are: 1) To establish an effective adolescent clinical trials unit to further the scientific agenda of the Adolescent Trials Network through the recruitment and retention of HIV-infected and at-risk HIV-uninfected pre-adolescents, adolescents, and young adults into biomedical and behavioral clinical trials; 2) To further develop existing community linkages to effectively establish a community-based primary prevention infrastructure that will support clinical trials of HIV prevention efforts, including vaccines, and other biomedical modalities; and 3) To contribute to the scientific agenda of the Adolescent Trials Network through the participation of investigators and site personnel in the development of protocol concept sheets and protocols. An ATU in Memphis would offer the combined advantages of an established, productive clinical research center with the proximity of a large at-risk population to maximize realization of the research efforts in the adolescent population.