LINKAGE ANALYSIS METHODS FOR HUMAN GENE MAPPING

描述(改编自《调查者摘要》)：长期目标 为基因连锁数据的统计分析提供新的方法 映射。预计结果将增加分析的可靠性和力量 方法：研究方法。在持续的基础上，最新版本的链接程序和 基因作图者普遍感兴趣的信息可免费提供 通过万维网(因特网)上的主页。正在进行的还有 出版一份联动通讯。 具体目标集中在人类基因组计划的三个领域。他们 解决统计遗传学中的方法论问题 开发新方法或改进现有方法。第一 两个具体目标是针对遗传图谱的方法学(与 强调复杂性状的基因本地化)，而最后一个具体目标 侧重于技术传播以及技术和方法 在基因图谱方面支持研究人员。提出了三个具体目标， 每个目标由少量组件组成。 目的1：全基因组连锁分析的方法：1)发展一种方法 分析基因图谱的趋势；1b)开发受影响的多基因座方法 SIB配对分析。 目标2：不平衡分析的方法：2)发展一种方法 多位点不平衡分析；2b)研究标记效应 不平衡上的杂合性。 目标3：传播方法：3a)维持一个文件传输协议/网站作为 遗传图谱信息资源；3b)执行新的 在计算机程序中开发的方法，将它们添加到当前 用于基因作图的计算机程序的集合，并维护和 更新这些计划；3)分发链接通讯；3)支持 用户在应用中通过协作联动方案 安排好了。

DESCRIPTION (Adapted from the Investigator's Abstract): The long-term goal is to provide new methods for statistical analysis of linkage data in gene mapping. Results are expected to increase reliability and power of analysis methods. On an on-going basis, up-to-date versions of linkage programs and information of general interest to gene mappers is freely made available through a home page on the world wide web (internet). Also on-going is the publication of a Linkage Newsletter. The specific aims focus on three areas of the human genome project. They address methodological problems in statistical genetics by proposing either development of new methods or improvement of existing methods. The first two specific aims are directed towards methodology in genetic mapping (with emphasis on localizing genes for complex traits) while the last specific aim focuses on dissemination of technology and on technical and methodological support of researchers in gene mapping. Three specific aims are proposed, with each aim consisting of a small number of components. Aim 1: Methods in genome-wide linkage analysis: 1a) To develop a method of analyzing trends in gene maps; 1b) To develop methods of multilocus affected sib pair analysis. Aim 2: Methods in disequilibrium analysis: 2a) To develop a method of multilocus disequilibrium analysis; 2b) To study the effects of marker heterozygosity on disequilibrium. Aim 3: Dissemination of methodology: 3a) To maintain an ftp/web site as a resource for information on genetic mapping; 3b) To implement newly developed methods in computer programs, to add them to the current collection of computer programs for genetic mapping, and to maintain and update these programs; 3c) To circulate a Linkage Newsletter; 3d) To support users in the application of linkage programs through collaborative arrangements.