RISK FACTORS FOR CVD IN WOMEN

女性心血管疾病的危险因素

• 批准号: 2692307
• 负责人: CHARLES H HENNEKENS
• 金额: $ 33.17万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-12-01 至 2002-08-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2692307
• 关键词: body physical activity; cardiovascular disorder; cardiovascular disorder epidemiology; clinical research; congestive heart failure; coronary disorder; death certificates; disease /disorder proneness /risk; female; hormone therapy; human subject; interview; longitudinal human study; medical records; myocardial infarction; nutrient intake activity; nutrition related tag; obesity; postmenopause; postmortem; questionnaires; stroke; sudden cardiac death; tobacco abuse

The plan is to continue investigation of determinants of cardiovascular disease (CVD) in a large, prospective cohort study of long duration, comprised of 121,700 US female registered nurses who have been followed since 1976 and are currently age 51-76 years. Continued follow-up will permit evaluation of a number of new and timely hypotheses regarding dietary and hormonal risk factors for coronary heart disease (CHD) as well as ischemic and hemorrhagic stroke. In addition, follow-up of two new and important endpoints, sudden cardiac death (SCD) and congestive heart failure (CHF), will be established, allowing them to examine the effect of atherogenic risk factors, physical activity and weight change on risk of SCD, as well as implement a methodology for confirming CHF. The Nurses' Health Study was begun in 1976 to study risk factors for breast cancer. In 1979, funding for risk factors of CVD was secured. Biennial mailed questionnaires gather detailed, updated information about a large number of exposures, including diet, smoking physical activity, postmenopausal hormone use, and psychosocial and behavioral factors. Incident reports of myocardial infarction and stroke are confirmed an classified by review of medical records, and similar procedures will be extended to confirm CHF and SCD. Fatal CVD events are documented by death certificates and confirmed by review of hospital medical records, autopsy reports and interviews with next of kin. Mortality follow-up exceeds 98 percent. The large size, prospective design, high follow-up rates, detailed and reliable long-term exposure and outcome information, and the availability of blood specimens on a large subgroup, combined with the relatively low cost, make this cohort a valuable and unique resource to study nutritional, hormonal and behavioral determinants of CVD in women. Continued funding of this grant will provide important new information about risk factors for CHD, stroke, SCD and CHF in this population of women who are now entering the age where CVD becomes the leading killer.

计划继续调查心血管疾病的决定因素， 在一项长期的大型前瞻性队列研究中， 包括121，700名美国注册女护士， 自1976年以来，目前年龄在51-76岁之间。 后续行动将 允许评估一些新的和及时的假设， 冠心病的饮食和激素风险因素， 以及缺血性和出血性中风 此外，两个后续 新的和重要的终点，心源性猝死（SCD）和充血性 心力衰竭（CHF），将建立，使他们能够检查 致动脉粥样硬化危险因素、体力活动和体重变化的影响 对SCD的风险，以及实施确认CHF的方法。 护士健康研究始于1976年，旨在研究 乳腺癌 1979年，针对心血管疾病风险因素的资金得到了保障。 每两年邮寄一次的调查问卷收集详细的最新信息 关于大量的接触，包括饮食，吸烟，身体 活动，绝经后激素使用，以及心理社会和行为 因素 心肌梗死和中风的事件报告是 通过审查医疗记录和类似资料， 将扩展程序以确认CHF和SCD。致死性CVD事件是 由死亡证明记录并经医院审查确认 医疗记录，尸检报告，还有对亲属的询问 死亡率随访超过98%。 大尺寸，前瞻性 设计、高随访率、详细可靠的长期暴露 和结果信息，以及血液样本的可用性， 大的亚组，加上相对较低的成本，使这个队列 一个宝贵的和独特的资源，研究营养，激素和 女性CVD的行为决定因素。 继续为此提供资金 赠款将提供有关冠心病危险因素的重要新信息， 中风，SCD和CHF在这一人群的妇女谁现在进入 CVD成为头号杀手的年龄。