Study on the elucidation and prevention for cardiovascular disorder by HACEK group oral bacteria

HACEK群口腔菌对心血管疾病的阐明和预防研究

• 批准号: 23390428
• 负责人: KOKEGUCHI Susumu
• 金额: $ 12.4万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390428/
• 关键词: 感染症; 歯周病細菌; HACEK群細菌; 心臓・血管疾患; A. actinomycetemcomitans; 口腔細菌; Aggregatibacter actinomycetemcomitans

Several microbiologic and epidemiologic studies have suggested an association between oral bacteria and systemic health such as diabetes, respiratory diseases and cardiovascular diseases. The HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) among oral bacteria are noted as the pathogens of infective endocarditis. The aim of this study is to determine the possible pathogenic factors of Aggregatibacter actinomycetemcomitans and oral methanogenic Archaea on infective endocarditis, and to analyze clinical and microbiological characteristics of the patients with infective endocarditis. Cell surface enolase and RNA chaperone protein, Hfq in A. actinomycetemcomitans and group II chaperonin of oral methanogenic Archaea were further characterized. The antimicrobial activity of inhibitor for methionine aminopeptidase and vitamin K analogues were also examined as a candidate of new therapeutic agents.

一些微生物学和流行病学研究表明，口腔细菌与糖尿病、呼吸系统疾病和心血管疾病等全身健康之间存在关联。在口腔细菌中，HACEK微生物（嗜血杆菌属、聚集杆菌属、人心杆菌属、腐蚀艾肯氏菌和金氏菌属）被认为是感染性心内膜炎的病原体。本研究旨在探讨伴放线菌聚集菌和口腔产甲烷菌在感染性心内膜炎中的可能致病因素，分析感染性心内膜炎患者的临床和微生物学特征。细胞表面烯醇化酶和RNA分子伴侣蛋白Hfq。放线菌伴放线菌和II组伴侣蛋白的口腔产甲烷菌的进一步表征。甲硫氨酸氨基肽酶抑制剂和维生素K类似物的抗菌活性也作为新的治疗药物的候选人进行了研究。

项目成果

Salivary Antioxidant Activity, Cytokines and Periodontitis: The Nagasaki Island Study

唾液抗氧化活性、细胞因子和牙周炎：长崎岛研究

• 发表时间: 2013
• 作者: Tamaki N;Yoshino F;Fukui M;Hayashida H;Yoshida A;Kitamura M;Kawasaki;Nakazato M;Maeda T;Kokeguchi S;Lee MC;Saito T;Ito H-O
• 通讯作者: Ito H-O

Medical microbiological approach to Archaea in oral infectious diseases

• DOI: 10.1016/j.jdsr.2013.01.002
• 发表时间: 2013-05
• 期刊: Japanese Dental Science Review
• 影响因子: 6.6
• 作者: H. Maeda;Kimito Hirai;Junji Mineshiba;Tadashi Yamamoto;S. Kokeguchi;S. Takashiba

Assessment of change in biofilm architecture by nutrient concentration using a multichannel microdevice flow system

• DOI: 10.1016/j.jbiosc.2012.09.018
• 发表时间: 2013-03-01
• 期刊: JOURNAL OF BIOSCIENCE AND BIOENGINEERING
• 影响因子: 2.8
• 作者: Sanchez, Zoe;Tani, Akio;Kimbara, Kazuhide
• 通讯作者: Kimbara, Kazuhide

Disseminated gonococcal infection in an elderly Japanese man.

一名日本老年男子传播淋球菌感染。

• 发表时间: 2013
• 期刊: Internal Medicine
• 影响因子: 1.2
• 作者: Hagiya H;Onishi N;Ebara H;Hanayama Y;Kokeguchi S;Nose M;Kusano N;Otsuka F.
• 通讯作者: Otsuka F.

Bacterial substitution of coagulase-negative staphylococci for streptococci on the oral mucosa after hematopoietic cell transplantation

造血细胞移植后口腔黏膜凝固酶阴性葡萄球菌替代链球菌

• DOI: 10.1007/s00520-010-0923-9
• 发表时间: 2011
• 期刊: Support Care Cancer
• 影响因子: 3.1
• 作者: Soga Y;Maeda Y;Ishimaru F;Tanimoto M;Maeda H;Nishimura F;Takashiba S
• 通讯作者: Takashiba S