Study on the elucidation and prevention for cardiovascular disorder by HACEK group oral bacteria

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Several microbiologic and epidemiologic studies have suggested an association between oral bacteria and systemic health such as diabetes, respiratory diseases and cardiovascular diseases. The HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) among oral bacteria are noted as the pathogens of infective endocarditis. The aim of this study is to determine the possible pathogenic factors of Aggregatibacter actinomycetemcomitans and oral methanogenic Archaea on infective endocarditis, and to analyze clinical and microbiological characteristics of the patients with infective endocarditis. Cell surface enolase and RNA chaperone protein, Hfq in A. actinomycetemcomitans and group II chaperonin of oral methanogenic Archaea were further characterized. The antimicrobial activity of inhibitor for methionine aminopeptidase and vitamin K analogues were also examined as a candidate of new therapeutic agents.