Discovering novel allosteric probes of muscarinic acetylcholine receptors

发现毒蕈碱乙酰胆碱受体的新型变构探针

• 批准号: DP190102950
• 负责人: Dr Celine Valant
• 金额: $ 37.29万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-06-03 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190102950
• 关键词: Discovering; novel; allosteric; probes; muscarinic

This project aims at fostering novel approaches to selectively target vital receptors in the human body, the muscarinic acetylcholine receptors (mAChRs). By harnessing the design of receptor mutations, compounds synthesis and fluorescent imaging, the project expects to develop new pharmacological tools for a family of receptors essential for the life of all vertebrates. By enriching our understanding of this family of receptor, the project expects to provide significant benefits to the research field by impacting on future drug discovery efforts, not only at mAChRs, but at other structurally related receptors.

该项目旨在培养新的方法来选择性地靶向人体中的重要受体，毒蕈碱乙酰胆碱受体（mAChRs）。通过利用受体突变、化合物合成和荧光成像的设计，该项目希望为所有脊椎动物的生命所必需的受体家族开发新的药理工具。通过丰富我们对这一受体家族的理解，该项目希望通过影响未来的药物发现工作，不仅在machr上，而且在其他结构相关的受体上，为研究领域提供显著的好处。