Understanding novel drug binding pockets at G protein-coupled receptors

了解 G 蛋白偶联受体上的新型药物结合口袋

• 批准号: nhmrc : 1082318
• 负责人: Dr Celine Valant
• 金额: $ 28.37万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-novel-drug-coupled-receptors/518869
• 关键词: Understanding; novel; drug; binding; pockets

Cell-surface proteins exhibit multiple secondary binding sites for which only synthetic drugs have been identified so far. My hypothesis is that these secondary binding sites are common to most proteins because they are primarily targeted by largely yet unidentified endogenously released molecules that can modify the biology of these proteins.

细胞表面蛋白表现出多个二级结合位点，到目前为止，只有合成药物被鉴定出来。我的假设是，这些二级结合位点对大多数蛋白质来说是常见的，因为它们主要是以大部分尚未识别的内源性释放分子为靶点，这些分子可以改变这些蛋白质的生物学特性。