HEALTH RELATED INTERVENTIONS FOR PERSONS LIVING WITH HIV

针对艾滋病毒感染者的健康相关干预措施

• 批准号: 2763645
• 负责人: ANKE A. EHRHARDT
• 金额: $ 74.48万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2763645
• 关键词: AIDS education /prevention; HIV infections; behavior modification; behavioral /social science research tag; clinical research; coping; handbook; health behavior; health care cost /financing; heterosexuals; homosexuals; human subject; human therapy evaluation; interview; intravenous drug abuse; psychotherapy; quality of life; socioeconomics

The goal of this project is to design and test an intervention to reduce sexual and injection practice risk behaviors among 1,200 HIV-infected men and women in order to decrease the likelihood that persons with HIV will transmit infection to others and to promote other health-related behavior changes in PLH. The research will be focused on three HIV+ subgroups: women, men who have sex with men (MSM), and injection drug users (IDUs). The study will be undertaken at four sites: Los Angeles, New York, San Francisco, and Milwaukee. The project will begin with a one-year period of formative Phase I studies conducted with 150 PLH (30 per site) using qualitative and life-history interviews to characterize the physical, social, and interpersonal contexts that influence risk behavior among PLH; understand stages of adaptation to serostatus; and identify barriers to implementation of safer sex, positive health care acts, and quality of life. The formative research phase will also allow us to tailor the social action theoretical model guiding the intervention to address issues affecting each subpopulation. Following the formative research phase, a manual will be prepared for an intervention of 15 individually-delivered sessions organized into three modules with components that target health promotion, transmission risk reduction, and psychological coping/relationship issues. In the Phase 2 main intervention trial, three subgroups of HIV-infected persons who have recently engaged in high-risk behavior will be recruited in equal numbers at each site yielding study-wide samples of HIV+ women (N=400), MSM (N=400), and IDUs (N=400). Altogether, 1,200 PLHs project-wide will be randomly assigned in equal numbers within each subgroup to an immediate intervention condition or to a lagged intervention control condition. Following two baseline interviews, participants will be evaluated at 5-month intervals for the next 35 months. In addition to anticipating changes in the primary (transmission risk acts) and secondary (health care behaviors and quality of life) outcomes over time and in response to each module, we will examine the impact of mediating factors emerging from social action theory (coping skills, social support, problem solving, HIV-related attitudes/beliefs, and environmental context of risk acts), as well as participant background factors (gender, ethnicity, history of transmission behaviors) on primary and secondary outcomes. The study will be implemented by a consortium of four sites in order to provide sufficient sample sizes to assess the impact of the intervention; to enhance generalizability of the findings; and to utilize the specialized expertise of each research team. Cost-effectiveness analyses, and dissemination are planned as part of this study.

本项目的目标是设计和测试一种干预措施， 1,200名艾滋病毒感染者的性行为和注射行为危险行为 男性和女性，以减少艾滋病毒感染者 将传染给他人，并促进其他与健康有关的 PLH的行为变化。 该研究将集中在三个艾滋病毒+ 亚组：女性、男男性行为者（MSM）和注射毒品者 用户（IDUs）。 该研究将在四个地点进行：洛杉矶， 纽约，弗朗西斯科和密尔沃基。 该项目将开始一个 为期一年的形成性I期研究进行了150 PLH（30 使用定性和生活史访谈来描述 影响风险的物理、社会和人际环境 行为之间的PLH;了解阶段的适应血清状态;和 确定实施更安全性行为、积极的卫生保健 行为和生活质量。形成性研究阶段还将允许 我们要量身定制社会行动理论模型， 采取干预措施，解决影响每个亚群的问题。 以下 在初步研究阶段，将编写一本手册， 15个单独提供的会议分为三个 模块包含针对健康促进和传播风险的组件 减少和心理应对/关系问题。 期 2主要干预试验，三个亚组的艾滋病毒感染者谁 最近从事高风险行为将被招募在平等 每个研究中心产生研究范围内HIV阳性女性样本的数量（N=400）， MSM（N=400）和IDUs（N=400）。 项目范围内总共将有1，200个PLH 在每个分组内以相等的数量随机分配给一个 立即干预条件或滞后干预控制 条件 在两次基线访谈之后，参与者将 在接下来的35个月里，每隔5个月进行一次评估。 除了 预测主要（传输风险行为）的变化， 随着时间的推移，次要（医疗保健行为和生活质量）结果 针对每个模块，我们将研究调解的影响， 社会行动理论中出现的因素（应对技能，社会 支持，解决问题，与艾滋病毒有关的态度/信念，以及 风险行为的环境背景）以及参与者背景 因素（性别、种族、传播行为史） 主要和次要结果。 这项研究将由一个 为了提供足够的样本量， 评估干预措施的影响;提高 研究结果;并利用每项研究的专门知识 团队 计划进行成本效益分析和传播， 这项研究的一部分。