LONG TERM NERVE REGENERATION THROUGH COLLAGEN DEVICES

通过胶原蛋白装置实现长期神经再生

• 批准号: 2796543
• 负责人: IOANNIS V YANNAS
• 金额: $ 19.22万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2796543
• 关键词: collagen; facial nerve; implant; laboratory rat; nerve injury; nervous system regeneration; neurophysiology; nonhuman therapy evaluation; tissue engineering; tissue support frame

DESCRIPTION (Adapted from the applicant's abstract) Injuries to the peripheral nervous system result in partial or total paralysis of the affected tissues if untreated, resulting in a significant quality of life deficit. Nerve injuries are a result of trauma, disease, and certain surgical procedures. For example, oncological surgery to remove tumors in the cranial base requires transection, and often resection, of the facial nerve. Current clinical treatments have led to incomplete and unsatisfactory recovery of motor and sensory function. Previous studies have shown the efficacy of a collagen-glycosaminoglycan (CG) matrix, ensheathed by a collagen nerve guide, to facilitate and enhance axonal regrowth. The long-term goal of the proposed study is to develop a resorbable collagen device that results in regeneration that meets or exceeds the current clinical standards. The proposed program is the result of the multiyear experience of the experimental team in synthesizing CG matrices and testing the response of injured tissues to these matrices. The primary focus of the research is on determination of the long-term recovery of peripheral nerves repaired with a family of collagen implants. Each objective varies one property of the implants: the presence or absence of a CG matrix filling a collagen tube, the length of gap injury the CG matrix is bridging, and the degradation rate of the collagen tube. Differences in the return of electrophysiological function and axonal structure will be evaluated between nerves regenerated through different collagen implants. The proposed study will provide quantitative information, not currently available, regarding the extent of steady state recovery compared to normal nerve, the effect of gap length on recovery of structure and function, and the optimum degradation rate of resorbable collagen tubes. It will also provide information on the kinetics of electrophysiological recovery of the regenerating nerve when treated with various implants and gap lengths. These data will be useful for all investigators studying the efficacy of devices for peripheral nerve regeneration.

描述 （改编自申请人摘要）周围神经损伤 系统导致受影响组织的部分或全部瘫痪， 未经治疗，导致生活质量严重下降。 神经 损伤是创伤、疾病和某些外科手术的结果。 例如，切除颅底肿瘤的肿瘤手术 需要横切面神经，通常是切除面神经。 电流 临床治疗导致了不完全和不满意的恢复， 运动和感觉功能。 以前的研究表明， 胶原-糖胺聚糖（CG）基质，被胶原神经包裹 引导，以促进和增强轴突再生。 的长期目标 拟议的研究是开发一种可吸收的胶原蛋白装置， 达到或超过当前临床标准的再生。 的 拟议的方案是多年经验的结果， 实验团队合成CG矩阵并测试 受伤的组织到这些基质中。 研究的主要重点是 周围神经修复后长期恢复的测定 胶原蛋白植入物家族。 每个目标都改变了 植入物：填充胶原管的CG基质的存在或不存在， CG基质桥接的间隙损伤长度，以及降解速率 胶原蛋白管。 电生理返回的差异 再生神经之间的功能和轴突结构将被评估 植入不同的胶原蛋白 这项研究将提供 目前尚不具备的关于 稳态恢复与正常神经相比，间隙长度对 结构和功能的恢复，以及最佳降解速率， 可吸收的胶原蛋白管。 它还将提供有关动力学的信息 再生神经的电生理恢复， 各种植入物和间隙长度。 这些数据对所有人都有用。 研究外周神经装置功效的研究人员 再生