LONG TERM NERVE REGENERATION THROUGH COLLAGEN DEVICES

通过胶原蛋白装置实现长期神经再生

• 批准号: 2796543
• 负责人: IOANNIS V YANNAS
• 金额: $ 19.22万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2796543
• 关键词: collagen; facial nerve; implant; laboratory rat; nerve injury; nervous system regeneration; neurophysiology; nonhuman therapy evaluation; tissue engineering; tissue support frame

DESCRIPTION (Adapted from the applicant's abstract) Injuries to the peripheral nervous system result in partial or total paralysis of the affected tissues if untreated, resulting in a significant quality of life deficit. Nerve injuries are a result of trauma, disease, and certain surgical procedures. For example, oncological surgery to remove tumors in the cranial base requires transection, and often resection, of the facial nerve. Current clinical treatments have led to incomplete and unsatisfactory recovery of motor and sensory function. Previous studies have shown the efficacy of a collagen-glycosaminoglycan (CG) matrix, ensheathed by a collagen nerve guide, to facilitate and enhance axonal regrowth. The long-term goal of the proposed study is to develop a resorbable collagen device that results in regeneration that meets or exceeds the current clinical standards. The proposed program is the result of the multiyear experience of the experimental team in synthesizing CG matrices and testing the response of injured tissues to these matrices. The primary focus of the research is on determination of the long-term recovery of peripheral nerves repaired with a family of collagen implants. Each objective varies one property of the implants: the presence or absence of a CG matrix filling a collagen tube, the length of gap injury the CG matrix is bridging, and the degradation rate of the collagen tube. Differences in the return of electrophysiological function and axonal structure will be evaluated between nerves regenerated through different collagen implants. The proposed study will provide quantitative information, not currently available, regarding the extent of steady state recovery compared to normal nerve, the effect of gap length on recovery of structure and function, and the optimum degradation rate of resorbable collagen tubes. It will also provide information on the kinetics of electrophysiological recovery of the regenerating nerve when treated with various implants and gap lengths. These data will be useful for all investigators studying the efficacy of devices for peripheral nerve regeneration.

描述 (改编自申请人的摘要)周围神经损伤 如果出现以下情况，系统会导致受影响组织的部分或全部瘫痪 不治疗，导致严重的生活质量缺陷。神经 伤害是由创伤、疾病和某些外科手术造成的。 例如，切除颅底肿瘤的肿瘤外科手术 需要横切，通常是切除面神经。当前 临床治疗导致不完全和不令人满意的恢复 运动和感觉功能。以前的研究已经表明， 胶原蛋白-糖胺聚糖(CG)基质，由胶原神经包裹 引导、促进和促进轴突再生。中国的长期目标是 拟议的研究是开发一种可吸收的胶原蛋白装置，其结果是 达到或超过当前临床标准的再生。这个 拟议的计划是多年经验的结果， 实验团队合成CG矩阵并测试 损伤组织移植到这些基质中。这项研究的主要焦点是 外周神经修复后远期恢复情况的测定 胶原蛋白植入物系列。每个目标都不同于 植入物：有或没有填充胶原管的CG基质， 缺口损伤的长度与CG基质的桥接，以及降解率 胶原蛋白管子。电生理学回归的差异 功能和轴突结构将在再生的神经之间进行评估 通过不同的胶原蛋白植入。拟议的研究将提供 数量信息，目前无法获得，关于 稳态恢复与正常神经相比，间隙长度对神经功能的影响 结构和功能的恢复和最佳降解率 可吸收胶原管。它还将提供有关动力学的信息 对再生神经电生理恢复的影响 各种植入物和缝隙长度。这些数据将对所有人都有用 研究人员研究周围神经装置的疗效 再生。