LONG TERM NERVE REGENERATION THROUGH COLLAGEN DEVICES

通过胶原蛋白装置实现长期神经再生

• 批准号: 6379899
• 负责人: IOANNIS V YANNAS
• 金额: $ 18.16万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6379899
• 关键词: collagen; facial nerve; implant; laboratory rat; medical implant science; nerve injury; nervous system regeneration; neurophysiology; nonhuman therapy evaluation; tissue engineering; tissue support frame

DESCRIPTION (Adapted from the applicant's abstract) Injuries to the peripheral nervous system result in partial or total paralysis of the affected tissues if untreated, resulting in a significant quality of life deficit. Nerve injuries are a result of trauma, disease, and certain surgical procedures. For example, oncological surgery to remove tumors in the cranial base requires transection, and often resection, of the facial nerve. Current clinical treatments have led to incomplete and unsatisfactory recovery of motor and sensory function. Previous studies have shown the efficacy of a collagen-glycosaminoglycan (CG) matrix, ensheathed by a collagen nerve guide, to facilitate and enhance axonal regrowth. The long-term goal of the proposed study is to develop a resorbable collagen device that results in regeneration that meets or exceeds the current clinical standards. The proposed program is the result of the multiyear experience of the experimental team in synthesizing CG matrices and testing the response of injured tissues to these matrices. The primary focus of the research is on determination of the long-term recovery of peripheral nerves repaired with a family of collagen implants. Each objective varies one property of the implants: the presence or absence of a CG matrix filling a collagen tube, the length of gap injury the CG matrix is bridging, and the degradation rate of the collagen tube. Differences in the return of electrophysiological function and axonal structure will be evaluated between nerves regenerated through different collagen implants. The proposed study will provide quantitative information, not currently available, regarding the extent of steady state recovery compared to normal nerve, the effect of gap length on recovery of structure and function, and the optimum degradation rate of resorbable collagen tubes. It will also provide information on the kinetics of electrophysiological recovery of the regenerating nerve when treated with various implants and gap lengths. These data will be useful for all investigators studying the efficacy of devices for peripheral nerve regeneration.

描述 （改编自申请人的摘要）伤害外周神经 系统会导致受影响组织的部分或全部麻痹 未经治疗，导致了很大的生活赤字。 神经 伤害是创伤，疾病和某些手术程序的结果。 例如，肿瘤手术以切除颅底肿瘤 需要面神经的横切，通常是切除。 当前的 临床治疗导致不完整和不令人满意的恢复 电机和感官功能。 先前的研究表明了 胶原 - 糖胺聚糖（CG）矩阵，由胶原神经包裹 指南，促进和增强轴突再生。 长期目标 拟议的研究是开发一种可吸收性胶原蛋白装置，以导致 符合或超过当前临床标准的再生。 这 建议的计划是多年经验的结果 实验团队合成CG矩阵并测试的响应 这些矩阵受伤的组织。 研究的主要重点是 确定用A修复的周围神经的长期恢复 胶原蛋白植入物家族。 每个目标都会改变 植入物：填充胶原管的CG基质的存在或不存在， 间隙损伤的长度CG矩阵正在桥接，降解率 胶原管。 电生理学回报的差异 将在神经再生之间评估功能和轴突结构 通过不同的胶原蛋白植入物。 拟议的研究将提供 有关范围的定量信息，目前尚不可用 与正常神经相比，稳态恢复，间隙长度对 结构和功能的恢复，以及最佳降解速率 可吸收胶原管。 它还将提供有关动力学的信息 用治疗后，再生神经的电生理恢复 各种植入物和间隙长度。 这些数据对所有人都有用 研究设备对周围神经的功效的研究者 再生。