CHEMICAL CONCEPTS FOR IMPROVED GLASS IONOMER SYSTEMS

改进玻璃离聚物系统的化学概念

• 批准号: 2796474
• 负责人: Bill M. Culbertson
• 金额: $ 20.75万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2000-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2796474
• 关键词: biomaterial development /preparation; biomaterial evaluation; carboxylate; chemical property; copolymer; dental adhesive /sealant; dental material wear; dental materials; gas chromatography; human tissue; nuclear magnetic resonance spectroscopy; oral facial restoration material; physical property; polyacrylate; polymerization; polymers; tensile strength; visible light

DESCRIPTION (Adapted from the Applicant's Abstract): Currently available glass ionomer formulations have many advantages, including adhesion to tooth structure and fluoride release, that contribute to their increasingly popular use in restorative dentistry and other applications. However, these materials suffer from relatively low compressive, tensile and flexural strengths compared to other longer-lasting restorative materials. The overall goal of this research is to develop polymeric matrix formulations for visible light-cured glass ionomer materials with improved properties. The three Aims are: 1.) to develop optimum backbone formulations with superior properties; 2.) to make these improved formulations curable by visible light and to optimize these formulations; and 3.) to further develop these formulations for additional improvements. The chemical approach that will dominate these physical improvements will focus on improving the copolymer flexibility and the availability of carboxylic acid groups for salt-bridge formation, an approach for which significant strength improvements have been demonstrated. The experimental approach will be to first optimize those compositions known to have maximum flexural strength, then to compare other properties such as working and setting times, tensile and compressive strengths, thermal expansion coefficient, solubility, adhesion to tooth structure, and fluoride release. A commercially available material will be used as control.

描述（改编自申请人的摘要）：目前可用 玻璃离聚物制剂具有许多优点，包括对牙齿的粘附性， 结构和氟化物释放，这有助于他们越来越多地 广泛用于牙科修复和其他应用。 但这些 材料遭受相对低的压缩、拉伸和弯曲 与其他更持久的修复材料相比， 的 本研究的总体目标是开发聚合物基质配方 用于具有改进性能的可见光固化玻璃离聚物材料。 这三个目标是：（1）。开发最佳骨架配方， 上级特性; 2.）为了使这些改进的制剂可通过以下步骤固化， 可见光和优化这些制剂;和3.）进一步发展 这些配方用于进一步的改进。 化学方法， 将主导这些身体的改善将集中在改善 共聚物的灵活性和羧酸基团的可用性， 盐桥的形成，这是一个方法， 已经证明了改进。 实验方法将是 首先优化那些已知具有最大弯曲强度的组合物， 然后比较其他性能，如工作和凝固时间，拉伸 和压缩强度，热膨胀系数，溶解度， 粘附到牙齿结构和氟化物释放。 市售 材料将用作对照。