LOADING EFFECTS ON THE TEMPOROMANDIBULAR JOINT DISC

颞下颌关节(TMJ)的关节内盘 改善关节配合、促进运动、分配关节载荷、保护 关节表面，涂抹润滑剂。然而相对较少的是 已知其在体内的功能以及与其之间的关系 化学结构和力学行为。通过检查属性 以及正常和非手术改变的椎间盘的特征 条件，这项研究将解决这些问题。目标是(1) 通过检查功能过程中椎间盘的活体变形 在圆盘的侧面植入应变传感器，(2) 用体外单轴方法评价腰椎间盘的材料性能 拉伸试验，(3)研究硫酸盐胶的类型、浓度和 电泳凝胶、液体闪烁在圆盘中的合成 计数[35S]标记和DMB分析，以及(4)检查 间盘的胶原纤维取向。实验对象，微型 猪，将被随机分组作为对照或 佩戴咬合变化夹板2个月。因为越靠前 髁状突负荷的位置应引起关节盘重塑，关节盘 受下颌骨前移位影响的动物 预计将显示(1)髋关节的前后变形减少 功能过程中的中间带；(2)粘弹性的减小 表现为较高的弹性模数和较低的极限强度点； (3)前部GAG增多，Biglycan大小移位 中间带蛋白多糖合成减少； 以及(4)中间体中的多向胶原纤维图案 前束带内纤维排列更平行。在 从长远来看，这项研究的结果将提供所需的信息 制定光盘行为的计算机模型，并将阐明 关节盘在颞下颌关节紊乱病中的作用

The intra-articular disc of the temporomandibular joint (TMJ) serves to improve joint fit, facilitate movements, distribute joint loads, protect articular surfaces, and spread lubrication. Yet relatively little is known about its function in vivo and about the relationship between its chemical structure and mechanical behavior. By examining the properties and characteristics of the disc in normal and nonsurgically altered conditions, this study will address these issues. The aims are (1) to examine the in vivo deformations of the disc during function by implanting a strain transducer into the lateral aspect of the disc, (2) to assess the material properties of the disc by in vitro uniaxial tension tests, (3) to investigate sulfated GAG type, concentration, and synthesis in the disc by electrophoresis gel, liquid scintillation counting of [35S] labeling, and DMB analysis, and (4) to inspect the collagen fiber orientation of the disc. Experimental subjects, miniature pigs, will randomly be placed in groups to function as controls or to wear occlusion altering splints for 2 months. Because the more anterior location of condylar loads should cause disc remodeling, the TMJ discs of animals subjected to anterior displacements of the mandible are expected to show (1) a decrease in the anteroposterior deformation of the intermediate band during function; (2) a diminution of viscoelastic behavior, a higher elastic modulus and a lower ultimate strength point; (3) an increase in GAGs and a size shift in biglycan in the anterior bands and a decrease in proteoglycan synthesis in the intermediate band; and (4) a multidirectional collagen fiber pattern in the intermediate band and a more parallel fiber arrangement in the anterior band. In the long term, the results of this study will provide information needed to formulate computer models of disc behavior and will shed light on the role of the disc in temporomandibular disorders.