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CARDIAC RENIN/ANGIOTENSIN SYSTEM IN HEART FAILURE

CARDIAC RENIN/ANGIOTENSIN SYSTEM IN HEART FAILURE
心力衰竭中的心脏肾素/血管紧张素系统
批准号:
6076381
负责人:
LAWRENCE S. ZISMAN
金额:
$6.55万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1995
资助国家:
美国
项目状态:
已结题
起止时间:
1995-08-01 至 2000-07-31

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中文摘要
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英文摘要
Several large clinical trials of angiotensin converting enzyme (ACE) inhibitors have demonstrated the critical role of the renin angiotensin system (RAS) in the pathogenesis of heart failure. These trials also indicate an unexplained heterogeneity in response to ACE-inhibitor therapy. The general hypothesis to be tested in this application is that there is variation in ACE activity in the falling human heart. An in vivo protocol using intracoronary 123I-Ang I will be used to study Ang II formation in the intact failing human heart.
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