EFFECT OF CARDIAC TISSUE SPECIFIC ANGIOTENSIN CONVERTING ENZYME INHIBITION

心肌组织特异性血管紧张素转换酶抑制的作用

• 批准号: 6275401
• 负责人: LAWRENCE S. ZISMAN
• 金额: $ 3.14万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6275401
• 关键词: ACE inhibitors; angiotensin II; clinical research; drug screening /evaluation; enalapril; heart disorder chemotherapy; heart metabolism; human subject; human therapy evaluation; idiopathic dilated cardiomyopathy; muscle stress; norepinephrine; peptidyl dipeptidase A; pharmacogenetics

Our hypotheses is that 1. In patients with idiopathic dilated cardiomyopathy, administration of the cardiac tissue specific ace- inhibitor, quinapril, significantly suppresses angiotensin ii formation compared to enalapril. The suppression is more pronounced in patients with the ace d/d genotype and 2. The additional suppression of ang ii afforded by quinapril correlates with a reduction in left ventricular (lv) wall stress, transmyocardial norepinephrine, and the net balance of cardiac protein synthesis.

我们的假设是1.扩张型 心肌病，心脏组织特异性ACE的施用， 抑制剂喹那普利显著抑制血管紧张素ii的形成 与依那普利相比。 这种抑制在患者中更为明显 具有ACE D/D基因型和2.对angii的额外抑制 喹那普利提供的与左心室（LV） 室壁应力、跨心肌去甲肾上腺素和 心脏蛋白质合成