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EFFECT OF CARDIAC TISSUE SPECIFIC ANGIOTENSIN CONVERTING ENZYME INHIBITION

EFFECT OF CARDIAC TISSUE SPECIFIC ANGIOTENSIN CONVERTING ENZYME INHIBITION
心肌组织特异性血管紧张素转换酶抑制的作用
批准号:
6114166
负责人:
LAWRENCE S. ZISMAN
金额:
$3.22万
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-12-01 至 1999-11-30

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英文摘要
Our hypotheses is that 1) in patients with idiopathic dilated cardio- myopathy, administration of the cardiac tissue specific ace-inhibitor, quinapril, significantly suppresses angiotensin II formation compared to enalapril The suppression is more pronounced in patients with the ace D/D genotype and 2) the additional suppression of ANG II afforded by quinapril correlates with a reduction in left ventricular (LV) wall stress, transmyocardial norepinephrine, and the net balance of cardiac protein synthesis.
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海外基金