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REGULATION OF MULTIDRUG RESISTANCE GENE EXPRESSION

REGULATION OF MULTIDRUG RESISTANCE GENE EXPRESSION
多药耐药基因表达的调控
批准号：
2700609
负责人：
KHEW-VOON CHIN
金额：
$7.24万
依托单位：
UNIV OF MED/DENT NJ-R W JOHNSON MED SCH
依托单位国家：
美国
项目类别：
财政年份：
1995
资助国家：
美国
项目状态：
已结题
起止时间：
1995-05-01 至 2000-04-30
来源：
https://reporter.nih.gov/project-details/2700609
关键词：
P glycoprotein cell type chloramphenicol acetyltransferase drug interactions flow cytometry gene deletion mutation gene expression genetic promoter element genetic regulation molecular cloning multidrug resistance neoplasm /cancer genetics neoplastic process nucleic acid sequence oncogenes regulatory gene tissue /cell culture transcription factor transfection tumor suppressor genes

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中文摘要
翻译
P53在mdr1表达调控中的作用对 对多药耐药发生机制的认识 癌症的表型。这些研究的结果可能会对 肿瘤进展过程中多药耐药基因激活的意义 与p53的基因改变有关，并可能提供 开发和设计特定治疗的新替代方案 针对人类恶性肿瘤的策略。
英文摘要
The role of p53 in the regulation of MDR1 expression is crucial to the understanding of the mechanisms of development of the multidrug resistance phenotype in cancers. Results from these studies could have significant implications for the activation of the MDR1 gene during tumor progression associated with genetic alterations in p53, and could potentially provide novel alternatives to the development and design of specific treatment strategies for human malignancies.
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