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REGULATION OF MULTIDRUG RESISTANCE GENE EXPRESSION

REGULATION OF MULTIDRUG RESISTANCE GENE EXPRESSION
多药耐药基因表达的调控
批准号：
2895292
负责人：
KHEW-VOON CHIN
金额：
$7.24万
依托单位：
UNIV OF MED/DENT NJ-R W JOHNSON MED SCH
依托单位国家：
美国
项目类别：
财政年份：
1995
资助国家：
美国
项目状态：
已结题
起止时间：
1995-05-01 至 2000-04-30
来源：
https://reporter.nih.gov/project-details/2895292
关键词：
P glycoprotein cell type chloramphenicol acetyltransferase drug interactions flow cytometry gene deletion mutation gene expression genetic promoter element genetic regulation molecular cloning multidrug resistance neoplasm /cancer genetics neoplastic process nucleic acid sequence oncogenes p53 gene /protein regulatory gene tissue /cell culture transcription factor transfection tumor suppressor genes

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中文摘要
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英文摘要
The role of p53 in the regulation of MDR1 expression is crucial to the understanding of the mechanisms of development of the multidrug resistance phenotype in cancers. Results from these studies could have significant implications for the activation of the MDR1 gene during tumor progression associated with genetic alterations in p53, and could potentially provide novel alternatives to the development and design of specific treatment strategies for human malignancies.
期刊论文(12)
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会议论文
Monitoring the expression profiles of doxorubicin-induced and doxorubicin-resistant cancer cells by cDNA microarray.
DOI： --
发表时间： 2000-08
期刊： Cancer research
影响因子： 11.2
作者： [K. Kudoh;M. Ramanna;R. Ravatn;A. Elkahloun;M. Bittner;P. Meltzer;J. Trent;W. Dalton;K. Chin]
通讯作者： K. Kudoh;M. Ramanna;R. Ravatn;A. Elkahloun;M. Bittner;P. Meltzer;J. Trent;W. Dalton;K. Chin
Transcriptional activation of the cyclin-dependent kinase inhibitor p21 by PML/RARalpha.
PML/RARalpha 对细胞周期蛋白依赖性激酶抑制剂 p21 的转录激活。
DOI： 10.1006/mcbr.1999.0121
发表时间： 1999
期刊： Molecular cell biology research communications : MCBRC
影响因子： --
作者： [Yang,WL, Zeng,YX, El-Deiry,WS, Nason-Burchenal,K, Dmitrovsky,E, Chin,KV]
通讯作者： Chin,KV
Extracellular catalytic subunit activity of the cAMP-dependent protein kinase in prostate cancer.
前列腺癌中 cAMP 依赖性蛋白激酶的细胞外催化亚基活性。
DOI： --
发表时间： 2000
期刊： Clinical cancer research : an official journal of the American Association for Cancer Research.
影响因子： --
作者： [Cvijic,ME, Kita,T, Shih,W, DiPaola,RS, Chin,KV]
通讯作者： Chin,KV
Regulation of P-glycoprotein expression in cyclic AMP-dependent protein kinase mutants.
环AMP依赖性蛋白激酶突变体中P-糖蛋白表达的调节。
DOI： --
发表时间： 1997
期刊： Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research
影响因子： --
作者： [Cvijic,ME, Chin,KV]
通讯作者： Chin,KV
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