RISK FACTORS FOR PERIODONTITIS IN HIV PATIENTS

HIV 患者牙周炎的危险因素

• 批准号: 2640887
• 负责人: Tamer Alpagot
• 金额: $ 3万
• 依托单位: UNIVERSITY OF THE PACIFIC-STOCKTON
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-04-01 至 2000-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2640887
• 关键词: AIDS; Actinobacillus actinomycetemcomitans; Bacteroides gingivalis; CD4 molecule; Fusobacterium nucleatum; HIV infections; beta glucuronidase; clinical research; dental plaque; disease /disorder proneness /risk; elastases; gram negative bacteria; human subject; immunofluorescence technique; longitudinal human study; monoclonal antibody; opportunistic infections; oral bacteria; periodontitis

The purpose of this study is to identify risk factors for periodontitis associated with HIV infection and to develop risk assessment models of periodontal disease in HIV infected patients. Periodontal disease affects a majority of the HIV seropositive individuals, and millions of dollars per year required to treat existing disease. It has been suggested that HIV infected individuals are at higher risk than others for the development of periodontal disease. Although previous studies by several groups in addition to ourselves have associated environmental and host factors with destructive periodontal diseases, there is a lack of information related to the risk factors and risk assessment models of periodontitis in HIV infected individuals. The specific aims are: 1) investigate the associations between biochemical components of gingival crevicular fluid (GCF), periodontopathic bacteria and clinical measures of periodontal disease in HIV infected individuals, 2) investigate the associations between immunological parameters, demographic variables, and clinical measures of periodontal status, and 3) construct risk assessment models of periodontal disease in HIV infected individuals. A longitudinal study of 225 HIV infected volunteers from the HIV CARE clinic at the University of the Pacific School of Dentistry serving a diverse HIV population (i.e. Whites, African-Americans, Hispanics, and Asians) will be performed to identify risk factors for periodontal disease over a six-month period. Study subjects will be seen at baseline and 6 month visits. Immunological variables, medical status, demographic variables and clinical measures of periodontal disease will be recorded. GCF and subgingival plaque samples will be collected from mesiobuccal sites of 4 lower incisors and upper right (or upper left) posterior sextant in each subject. By identifying the risk factors for periodontal disease, high risk individuals can be targeted and preventive measures can be taken to intercept the disease process with therapy.

这项研究的目的是确定 牙周炎与HIV感染相关并发展风险 感染HIV的牙周疾病的评估模型 患者。 牙周疾病影响大多数艾滋病毒 血清阳性个人，每年数百万美元 需要治疗现有疾病。 有人建议艾滋病毒 受感染的人的风险比其他人更高 牙周疾病。 尽管以前由几个小组进行了研究 除我们自己还具有相关的环境和宿主因素 由于牙周疾病而缺乏信息 与牙周炎的风险因素和风险评估模型有关 在艾滋病毒感染的人中。 具体目的是：1）研究 牙龈裂缝液（GCF）的生化成分， 牙周病细菌和牙周疾病的临床指标 在艾滋病毒感染的个体中，2）研究 免疫学参数，人口统计学变量和临床指标 牙周状态和3）构建风险评估模型 艾滋病毒感染个体的牙周病。 一项对来自HIV护理的225名HIV感染志愿者的纵向研究 太平洋大学牙科学院的诊所服务 多样化的艾滋病毒人群（即白人，非裔美国人，西班牙裔和 将进行亚洲人）以确定牙周风险因素 六个月内的疾病。 研究科目将在 基线和6个月访问。 免疫变量，医学状况， 人口统计学变量和牙周疾病的临床指标将 被记录。 将从 4个下门牙和右上方（或左上方）的中孔位点 每个受试者的后六角体。 通过确定风险因素 牙周病，高风险个体可以针对目标，并且 可以采取预防措施以拦截疾病过程 治疗。