EPIDEMIOLOGY OF CARDIAC DEVELOPMENT IN YOUTH

描述 （摘自申请人摘要）本研究的目的是 在混合纵向设计的基础上阐明心脏的变化， 结构和功能，发生在童年后期和青春期。 提出了四个目标：1）记录变化的性质和程度， 心脏结构，基于M模式测量和指数并开发 相应的参考值; 2）记录的性质和程度 性别和少数群体 在参加心跳计划的678名参与者中，136例（20.1%） 非裔美国人，506例（74.6%）为高加索人，25例（3.7%）为西班牙裔，7例（2.7%）为 （1%）是亚洲人，4（0.6%）是美洲原住民。 333例（49.1%）为女性 男性345例（50.9%）。 按性别和性别分列的后续行动完成情况 没有提供种族。 81.4%的研究组参加了所有 计划检查，90.9%的受试者有资格接受至少10次检查 完成10次或以上考试。 预算 在第一年的其他费用项下，“出版物、介绍、 （图形，页面费用）”从1000美元减少到250美元，因为大多数 这类费用将在第二年发生。 两年，在 考虑到专业知识， 团队的一员 建议将资助期缩短至18个月， 因此，将第二年的预算减少一半。

DESCRIPTION (Adapted from the applicant's abstract) The goal of this research is to elucidate on the basis of a mixed longitudinal design the changes in cardiac structure and function which occur during late childhood and adolescence. Four aims are presented: 1) to document the nature and extent of changes in cardiac structure, based on M-mode measurements and indices and develop corresponding reference values; 2) to document the nature and extent of GENDER AND MINORITIES Of the 678 participants enrolled in Project HeartBeat!, 136 (20.1%) were African-American, 506 (74.6%) were Caucasian, 25 (3.7%) were Hispanic, 7 (1%) were Asian, and 4 (0.6%) were Native American. 333 (49.1%) were female and 345 (50.9%) were male. Completeness of follow-up by gender and ethnicity is not provided. 81.4% of the total study group attended all scheduled examinations, and 90.9% of subjects eligible for at least 10 examinations completed 10 or more exams. BUDGET Under Other Expenses in Year 1, the budget for "Publications, presentations, (graphics, page charges)" is reduced from $1000 to $250, since most of the costs incurred in this category will occur in Year 2. Two full years at the FTE proposed appears excessive for the work described, given the expertise of the team. It is recommended to reduce the funding period to 18 months, and therefore reduce the requested budget for Year 2 by one-half.