EPIDEMIOLOGY OF CARDIAC DEVELOPMENT IN YOUTH

描述 (改编自申请者的摘要)这项研究的目的是 在混合纵向设计的基础上阐明心脏的变化 发生在儿童后期和青春期的结构和功能。 提出了四个目标：1)记录变化的性质和程度 基于M型测量和指数的心脏结构和开发 相应的参考值；2)记录以下内容的性质和范围 性别和少数群体 在参加心跳项目的678名参与者中，有136人(20.1%) 非洲裔美国人，506人(74.6%)是高加索人，25人(3.7%)是西班牙裔，7 (1%)是亚洲人，4(0.6%)是美洲原住民。333人(49.1%)为女性 男性345人，占50.9%。按性别和性别分列的后续行动的完整性 不提供种族问题。81.4%的研究组成员参加了所有 定期考试，90.9%的科目符合至少10分的条件 考试完成10次或更多考试。 预算 在第一年其他支出项下，“出版物、演示文稿、 (图形、页面费用)“从1000美元降至250美元，因为大多数 这一类别产生的费用将发生在第二年。 考虑到专业知识，建议的FTE对于所描述的工作来说似乎过高 团队中的一员。建议将资金期限缩短至18个月， 并因此将所要求的第二年预算减少一半。

DESCRIPTION (Adapted from the applicant's abstract) The goal of this research is to elucidate on the basis of a mixed longitudinal design the changes in cardiac structure and function which occur during late childhood and adolescence. Four aims are presented: 1) to document the nature and extent of changes in cardiac structure, based on M-mode measurements and indices and develop corresponding reference values; 2) to document the nature and extent of GENDER AND MINORITIES Of the 678 participants enrolled in Project HeartBeat!, 136 (20.1%) were African-American, 506 (74.6%) were Caucasian, 25 (3.7%) were Hispanic, 7 (1%) were Asian, and 4 (0.6%) were Native American. 333 (49.1%) were female and 345 (50.9%) were male. Completeness of follow-up by gender and ethnicity is not provided. 81.4% of the total study group attended all scheduled examinations, and 90.9% of subjects eligible for at least 10 examinations completed 10 or more exams. BUDGET Under Other Expenses in Year 1, the budget for "Publications, presentations, (graphics, page charges)" is reduced from $1000 to $250, since most of the costs incurred in this category will occur in Year 2. Two full years at the FTE proposed appears excessive for the work described, given the expertise of the team. It is recommended to reduce the funding period to 18 months, and therefore reduce the requested budget for Year 2 by one-half.