PRECURSORS OF CVD RISK FACTORS--PROJECT HEARTBEAT

CVD危险因素的前兆——项目心跳

• 批准号: 2387404
• 负责人: DARWIN R. LABARTHE
• 金额: $ 2.97万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-30 至 1998-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2387404
• 关键词: adolescence (12-20); bioenergetics; blood lipid; blood pressure; body composition; body physical activity; body physical characteristic; body weight; caloric dietary content; cardiovascular disorder epidemiology; clinical research; disease /disorder proneness /risk; human subject; middle childhood (6-11); sex hormones

The goal of this research is to elucidate the changes in body size, composition, and configuration occurring in adolescence, because these are important precursors of change in blood pressure and blood lipids. Hypotheses to be tested concern: (1) the time patterns of change in several indicators of body size, composition and configuration over the period of observation; (2)the relations between the time patterns of change in these indicators and the corresponding patterns for change in selected endocrine factors; and (3) the explanatory contributions of energy intake and expenditure to variation between individuals in their observed time patterns of change in these indicators. The anthropometric indicators to be addressed are: weight (total mass), height, body mass index (BMI, wt/ht2), fat-free mass, fat mass, per cent body fat, and fat distribution (waist/hip ratio). Each of these indicators will be examined first separately and then in relation to selected endocrinologic measures (testosterone, estradiol, and DHEAS) and to energy intake and expenditure (from interview histories of diet and physical activity). Existing data from up to twelve 4-monthly examinations over the age range from 8-17 years conducted in Project HeartBeat! will be analyzed. Project HeartBeat! was uniquely designed to investigate the course of change in CVD risk factors and several categories of covariates, including the anthropometric indicators addressed in this proposal. The data pertain to the 678 participants who entered the Project in 1991-93 at ages 8, 11 or 14 years of age, of whom 49.1% were female and 20.1% were black. of the 395 participants who became eligible for 10 or more 4-monthly examinations, 349 (88.4%) completed at least 10 occasions; 538 participants of 556 who were eligible for 7 or more examinations (96.8%) completed at least 7. Multi-level (MLn) analytic methods previously tested with other Project data will be utilized for this analysis. The data set is in electronic format and is immediately accessible to the Principal Investigator. The results will demonstrate the dynamics of change in these fundamental measures of body size, composition and configuration, identify their relationships with major hormonal and behavioral factors, and contribute to improvements in intervention strategies aimed at modification of blood pressure and blood lipids.

这项研究的目的是阐明身体大小的变化， 组成，和配置发生在青春期，因为这些 是血压和血脂变化的重要前兆。 有待检验的假设涉及：（1） 整个过程中身体尺寸、组成和配置的几个指标 观察期;（2）时间模式之间的关系 这些指标的变化以及 选定的内分泌因素;和（3）的解释性贡献 能量摄入和消耗的个体之间的差异， 观察这些指标变化的时间模式。 的 要解决的人体测量指标是：体重（总质量）， 身高、体重指数（BMI，wt/ht 2）、无脂肪质量、脂肪质量，百分比 身体脂肪和脂肪分布（腰/臀比）。这一切成功都 指标将首先单独审查，然后与 选定的内分泌指标（睾酮、雌二醇和DHEAS） 以及能量摄入和消耗（来自饮食访谈历史 身体活动）。现有数据最多可达12个，每4个月一次 在项目中对8至17岁的儿童进行了检查， 心跳！将被分析。心跳计划！设计独特 研究CVD危险因素的变化过程， 协变量类别，包括人体测量指标 在这个提案中。数据涉及678名参与者， 在1991-93年8岁、11岁或14岁时进入该项目，其中 49.1%为女性，20.1%为黑人。 在395名参与者中， 有资格参加10次或以上4个月一次的检查，349人（88.4%） 至少完成了10次; 556名参与者中有538名参与者 有资格参加7次或以上考试（96.8%），至少完成7次。 多层次（MLn）分析方法以前测试过其他项目 数据将用于该分析。数据集是电子的 格式，主要研究者可立即访问。 的 结果将展示这些基本要素的变化动态 测量身体大小、组成和结构，确定其 与主要的荷尔蒙和行为因素的关系，并有助于 改善干预战略， 血压和血脂。