PRECURSORS OF CVD RISK FACTORS--PROJECT HEARTBEAT

这项研究的目的是阐明身体大小的变化， 青春期的组成和构型，因为这些 是血压和血脂变化的重要前兆。 有待检验的假设涉及：(1)变化的时间模式 身体大小、成分和形态的几个指标 观察期；(2)时间模式之间的关系 这些指标的变化以及#年的相应变化模式 选定的内分泌因素；以及(3) 能量摄入和消耗对不同个体之间的差异 观察到这些指标变化的时间模式。这个 需要解决的人体测量指标有：体重(总质量)， 身高，体重指数(BMI，wt/HT2)，脱脂质量，脂肪质量，百分比 身体脂肪和脂肪分布(腰臀比)。这其中的每一个 指标将首先单独检查，然后与 选定的内分泌学指标(睾酮、雌二醇和脱氢表雄酮) 以及能量摄入和消耗(来自饮食的访谈历史 和体力活动)。最多12个4个月的现有数据 在项目中进行的8-17岁以上的考试 心跳！将会被分析。心跳计划！是独一无二的设计 探讨心脑血管疾病危险因素的变化过程及几个 协变量类别，包括人体测量指标 在本提案中提到的。这些数据与678名参与者有关，他们 在1991-93年度以8岁、11岁或14岁的年龄参加该项目，其中 49.1%为女性，20.1%为黑人。在395名参与者中， 符合参加10次或以上4个月考试的资格，349人(88.4%) 完成至少10次；556名参与者中的538名 有资格参加7次或以上考试的(96.8%)至少完成7次。 以前用其他项目测试过的多层次(MLN)分析方法 数据将被用于这一分析。数据集是电子版的 格式，首席调查员可以立即访问。这个 结果将展示这些基本要素的动态变化 身体大小、成分和形态的测量，确定它们的 与主要荷尔蒙和行为因素的关系，并对 改进干预战略，旨在修改 血压和血脂。

The goal of this research is to elucidate the changes in body size, composition, and configuration occurring in adolescence, because these are important precursors of change in blood pressure and blood lipids. Hypotheses to be tested concern: (1) the time patterns of change in several indicators of body size, composition and configuration over the period of observation; (2)the relations between the time patterns of change in these indicators and the corresponding patterns for change in selected endocrine factors; and (3) the explanatory contributions of energy intake and expenditure to variation between individuals in their observed time patterns of change in these indicators. The anthropometric indicators to be addressed are: weight (total mass), height, body mass index (BMI, wt/ht2), fat-free mass, fat mass, per cent body fat, and fat distribution (waist/hip ratio). Each of these indicators will be examined first separately and then in relation to selected endocrinologic measures (testosterone, estradiol, and DHEAS) and to energy intake and expenditure (from interview histories of diet and physical activity). Existing data from up to twelve 4-monthly examinations over the age range from 8-17 years conducted in Project HeartBeat! will be analyzed. Project HeartBeat! was uniquely designed to investigate the course of change in CVD risk factors and several categories of covariates, including the anthropometric indicators addressed in this proposal. The data pertain to the 678 participants who entered the Project in 1991-93 at ages 8, 11 or 14 years of age, of whom 49.1% were female and 20.1% were black. of the 395 participants who became eligible for 10 or more 4-monthly examinations, 349 (88.4%) completed at least 10 occasions; 538 participants of 556 who were eligible for 7 or more examinations (96.8%) completed at least 7. Multi-level (MLn) analytic methods previously tested with other Project data will be utilized for this analysis. The data set is in electronic format and is immediately accessible to the Principal Investigator. The results will demonstrate the dynamics of change in these fundamental measures of body size, composition and configuration, identify their relationships with major hormonal and behavioral factors, and contribute to improvements in intervention strategies aimed at modification of blood pressure and blood lipids.