RICE ORS WITH HIV ASSOCIATED DIARRHEA

描述（摘自应用程序） 长期目标是最大限度地适当使用口服补液 作为一种简单而廉价的治疗成人脱水的治疗方法， 艾滋病相关腹泻。 使用大米口服补液溶液 （RB-ORS），患有HIV相关腹泻的脱水患者应能够 更换液体，保持水合作用和电解质平衡，从而a） 减少住院和静脉输液的需要，B）增加 患者独立生活的能力，c）减少与脑卒中相关的 通过减少排泄量和持续时间来降低发病率。 具体地说， 该研究应表明：a）RB-ORS将有效地再水合并维持 在大多数患有腹泻的HIV感染的成人中，补液，B） 用RB-ORS治疗不会有不良反应，c）患者 与静脉注射治疗相比，将首选RB-ORS作为补液方法。 这将是一项随机临床试验，30例艾滋病毒相关性 医生认为需要静脉输液的腹泻患者 因为有脱水的客观迹象 他们将被随机分配到 接受RB-ORS（n=20）或静脉补液（n=10）， 将在约翰霍普金斯医院接受监测时接受这种治疗 临床研究中心两天。 使用客观的措施， 再水化（体重、液体摄入量和排出量、连续血细胞比容和 总蛋白测量和系列生物阻抗），成功率和 将记录两种治疗的改善率。 接受RB-ORS但未再水化的患者将接受 I.V. 's.如果大部分病人都能成功补充水分 并与RB-ORS一起维护，将确定RB-ORS的有用性。

DESCRIPTION (Taken from application) The long term goal is to maximize the appropriate use of oral rehydration therapy as a simple and inexpensive treatment for dehydration in adults with HIV-associated diarrhea. Using rice-based oral rehydration solution (RB-ORS), dehydrated patients with HIV-associated diarrhea should be able to replace fluids, maintain hydration and electrolyte balance and thereby a) lessen the need for hospitalization and intravenous fluids, b) increase the ability of the patients to live independently, c) lessen diarrhea-associated morbidity by decreasing the volume and duration of purging. Specifically, the study should show a) that RB-ORS will effectively rehydrate and maintain hydration in most HIV infected adults with diarrhea, b) that the rehydration treatment with RB-ORS will have no untoward effects, and c) that patients will prefer RB-ORS as a means of rehydration compared to I.V. treatment. This will be a randomized clinical trial of 30 patients with HIV-associated diarrhea who are felt to require intravenous fluids by their physician because of objective signs of dehydration. They will be randomized to receive either RB-ORS (n=20) or intravenous rehydration (n=10), and they will receive this treatment while being monitored in Johns Hopkins Hospital General Clinical Research Center for two days. Using objective measures of rehydration (body weight, fluid intake and output, serial hematocrit and total protein measurements, and serial bioimpedence), the success rate and the rate of improvement with the two treatments will be documented. Patients who receive RB- ORS but are not rehydrated will be placed on I.V.'s. If a high proportion of the patients can be successfully rehydrated and maintained with RB-ORS, the usefulness of RB-ORS will be established.