RICE ORS WITH HIV ASSOCIATED DIARRHEA

描述(取自应用程序) 长期目标是最大限度地适当使用口服补液。 作为一种简单而廉价的治疗成人脱水的方法 艾滋病毒相关性腹泻。大米口服液的使用 (RB-ORS)，患有HIV相关性腹泻的脱水患者应该能够 更换液体，保持水合和电解质平衡，从而 减少住院和静脉输液的需要，b)增加 患者独立生活的能力，c)减少与腹泻相关的 通过减少通便的量和持续时间来减少发病率。具体来说， 这项研究应该表明a)RB-ORS将有效地复水并保持 大多数HIV感染的成年人腹泻时的补水，b)补水 使用RB-ORS治疗不会有不良反应，以及c)患者 与静脉注射治疗相比，更倾向于使用RB-ORS作为补液手段。 这将是一项针对30名HIV相关患者的随机临床试验。 医生认为需要静脉输液的腹泻患者 因为客观上有脱水的迹象。他们将被随机分配到 接受RB-ORS(n=20)或静脉补液(n=10)，他们 将在约翰霍普金斯医院接受监测期间接受这种治疗 综合临床研究中心，为期两天。使用客观的衡量标准 补液(体重、液体摄入量和排出量、连续血细胞比容和 总蛋白测量和连续生物阻抗)、成功率和 这两种治疗的改善率将被记录下来。 接受RB-ORS但未复水的患者将被安置在 S。如果有很高比例的患者能够成功地进行补液 并与RB-ORS一起维护，RB-ORS的有用性将被确立。

DESCRIPTION (Taken from application) The long term goal is to maximize the appropriate use of oral rehydration therapy as a simple and inexpensive treatment for dehydration in adults with HIV-associated diarrhea. Using rice-based oral rehydration solution (RB-ORS), dehydrated patients with HIV-associated diarrhea should be able to replace fluids, maintain hydration and electrolyte balance and thereby a) lessen the need for hospitalization and intravenous fluids, b) increase the ability of the patients to live independently, c) lessen diarrhea-associated morbidity by decreasing the volume and duration of purging. Specifically, the study should show a) that RB-ORS will effectively rehydrate and maintain hydration in most HIV infected adults with diarrhea, b) that the rehydration treatment with RB-ORS will have no untoward effects, and c) that patients will prefer RB-ORS as a means of rehydration compared to I.V. treatment. This will be a randomized clinical trial of 30 patients with HIV-associated diarrhea who are felt to require intravenous fluids by their physician because of objective signs of dehydration. They will be randomized to receive either RB-ORS (n=20) or intravenous rehydration (n=10), and they will receive this treatment while being monitored in Johns Hopkins Hospital General Clinical Research Center for two days. Using objective measures of rehydration (body weight, fluid intake and output, serial hematocrit and total protein measurements, and serial bioimpedence), the success rate and the rate of improvement with the two treatments will be documented. Patients who receive RB- ORS but are not rehydrated will be placed on I.V.'s. If a high proportion of the patients can be successfully rehydrated and maintained with RB-ORS, the usefulness of RB-ORS will be established.