MOLECULAR ENCAPSULATION VIA SELF ASSEMBLING CAVITANDS

通过自组装空穴进行分子封装

• 批准号: 2750144
• 负责人: JOHN C SHERMAN
• 金额: $ 8万
• 依托单位: UNIVERSITY OF BRITISH COLUMBIA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2750144
• 关键词: chemical aggregate; chemical binding; chemical bond; chemical synthesis; intermolecular interaction; molecular shape

DESCRIPTION: Complex assemblies are ubiquitous in nature and in materials science. DNA, microtubules, and cell membranes are but a few biological assemblies that owe their structural integrity to noncovalent interactions. Liquid crystals, monolayers and nanotubes are some types of materials that are likewise structurally well-defined. Organic chemists are in hot pursuit of ways to design, synthesize, and characterize new assemblies of such high structural complexity, with the hope that the new assemblies will be as useful as they are complex. Potential uses include transport devices, separation devices, switches, catalysts, and sensors. The general aim of this proposal is to create complex assemblies using organic modules, linking them either covalently (permanently) or noncovalently (reversibly) in well-defined manners. The assemblies will contain small molecules, encapsulated within and holding together the assemblies. Characterization of these assemblies will provide a contribution to the general understanding of the role of weak noncovalent interactions in molecular recognition and in the assembly process to form materials and biological assemblies. Various applications (vide infra) will be explored. Any contribution to the understanding of noncovalent interactions and how they relate to assembly processes would be invaluable to biomedical research. The interactions that are examined in this proposal are the same as those involved in the inhibition of enzyme activity, the antagonistic blocking of cell receptors, the intercalation of drugs with DNA, the bundling of microtubules, the organization of cell membranes, etc. In addition, there are potential applications that are directly relevant to health research, including transport of large guest molecules (these could be drugs) through membranes, tissue-specific drug-delivery devices, catalysis of biologically relevant reactions, and the detection and/or removal of toxins.

描述：复杂的组件在自然界和材料中无处不在 科学 DNA、微管和细胞膜只是一些生物学上的 组装体的结构完整性归功于非共价相互作用。 液晶、单层和纳米管是一些类型的材料， 在结构上也是明确的。 有机化学家们正积极地 设计，合成和表征这种高性能的新组件的方法 结构的复杂性，希望新的大会将作为 因为它们很复杂，所以很有用。 潜在用途包括运输设备， 分离装置、开关、催化剂和传感器。 的总体目标 这个建议是使用有机模块创建复杂的组件， 它们以共价（永久）或非共价（可逆）的方式 明确的举止 组装体将包含小分子， 封装在组件内并将组件保持在一起。 表征 这些会议将有助于对 弱非共价相互作用在分子识别和 形成材料和生物组装体的组装过程。 各种 应用（见下文）。 对理解非共价相互作用以及如何 它们与组装过程有关， research. 本建议书中检查的相互作用是相同的 作为参与酶活性抑制的那些，拮抗剂 阻断细胞受体，药物与DNA的嵌入， 微管的集束，细胞膜的组织等。 此外，还有直接相关的潜在应用， 健康研究，包括大客体分子的运输（这些可以 是药物）通过膜，组织特异性药物递送装置， 生物相关反应的催化，以及检测和/或 清除毒素。