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MOLECULAR ENCAPSULATION VIA SELF ASSEMBLING CAVITANDS

通过自组装空穴进行分子封装

基本信息

批准号：
6019293
负责人：
JOHN C SHERMAN
金额：
$ 8万
依托单位：
UNIVERSITY OF BRITISH COLUMBIA
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-08-01 至 2000-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6019293
关键词：
chemical aggregate chemical binding chemical bond chemical synthesis intermolecular interaction molecular shape nanotechnology

项目摘要

DESCRIPTION: Complex assemblies are ubiquitous in nature and in materials science. DNA, microtubules, and cell membranes are but a few biological assemblies that owe their structural integrity to noncovalent interactions. Liquid crystals, monolayers and nanotubes are some types of materials that are likewise structurally well-defined. Organic chemists are in hot pursuit of ways to design, synthesize, and characterize new assemblies of such high structural complexity, with the hope that the new assemblies will be as useful as they are complex. Potential uses include transport devices, separation devices, switches, catalysts, and sensors. The general aim of this proposal is to create complex assemblies using organic modules, linking them either covalently (permanently) or noncovalently (reversibly) in well-defined manners. The assemblies will contain small molecules, encapsulated within and holding together the assemblies. Characterization of these assemblies will provide a contribution to the general understanding of the role of weak noncovalent interactions in molecular recognition and in the assembly process to form materials and biological assemblies. Various applications (vide infra) will be explored. Any contribution to the understanding of noncovalent interactions and how they relate to assembly processes would be invaluable to biomedical research. The interactions that are examined in this proposal are the same as those involved in the inhibition of enzyme activity, the antagonistic blocking of cell receptors, the intercalation of drugs with DNA, the bundling of microtubules, the organization of cell membranes, etc. In addition, there are potential applications that are directly relevant to health research, including transport of large guest molecules (these could be drugs) through membranes, tissue-specific drug-delivery devices, catalysis of biologically relevant reactions, and the detection and/or removal of toxins.

描述：复杂的组件在自然界和材料中无处不在科学。DNA、微管和细胞膜只是几种生物将其结构完整性归因于非共价相互作用的组装体。液晶、单分子膜和纳米管是某些类型的材料在结构上也同样定义得很好。有机化学家热衷于追逐设计、合成和表征如此高的新组件的方法结构复杂，希望新的程序集将像因为它们很复杂，所以很有用。潜在的用途包括运输设备，分离设备、开关、催化剂和传感器。的总体目标是这项提议是使用有机模块、链接来创建复杂的组件它们要么共价(永久)，要么非共价(可逆) 举止得体。这些组件将包含小分子，封装在组件内并将其保持在一起。表征这些大会将有助于全面理解弱非共价相互作用在分子识别中的作用形成材料和生物组装的组装过程。五花八门将探索应用程序(见下文)。对理解非共价相互作用以及如何它们与组装过程有关，对生物医学来说是无价的研究。本建议书中考察的交互作用是相同的由于参与了酶活性的抑制，拮抗剂阻断细胞受体，药物与DNA的嵌入，微管的捆绑、细胞膜的组织等此外，还有一些与以下内容直接相关的潜在应用健康研究，包括大客体分子的运输(这些可能是药物)通过膜，组织特异性药物输送装置，生物相关反应的催化，以及检测和/或清除毒素。